NHE3-IN-1

• CAT Number: I020283
• CAS Number: 632355-68-1
• Molecular Formula: C₁₂H₁₀ClN₃S
• Molecular Weight: 263.75
• Purity: ≥95%
• Target: Na+/H+ Exchanger (NHE)
• IUPAC Name: N-(2-chloro-4-methylthiophen-3-yl)-1H-benzimidazol-2-amine
• InChI: InChI=1S/C12H10ClN3S/c1-7-6-17-11(13)10(7)16-12-14-8-4-2-3-5-9(8)15-12/h2-6H,1H3,(H2,14,15,16)
• InChIKey: VCZHIOCRVCECIJ-UHFFFAOYSA-N
• SMILES: CC1=CSC(=C1NC2=NC3=CC=CC=C3N2)Cl

NHE3-IN-1（Cat No.:I020283）is a selective small-molecule inhibitor of the sodium-hydrogen exchanger 3 (NHE3), a membrane protein primarily expressed in the kidneys and intestines. NHE3 plays a critical role in sodium and fluid homeostasis by exchanging sodium ions for hydrogen ions. By inhibiting NHE3, NHE3-IN-1 can reduce sodium absorption, potentially offering therapeutic benefits in conditions like heart failure, hypertension, and kidney diseases where fluid retention and electrolyte imbalance are prevalent. Preclinical studies suggest that targeting NHE3 may help manage conditions involving abnormal sodium and fluid regulation, such as edema and hypervolemia.