NHPI-PEG4-C2-NHS ester

• CAT Number: I017760
• CAS Number: 1415328-95-8
• Molecular Formula: C₂₃H₂₈N₂O₁₁
• Molecular Weight: 508.48
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(1,3-dioxoisoindol-2-yl)oxyethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C23H28N2O11/c26-19-5-6-20(27)24(19)36-21(28)7-8-31-9-10-32-11-12-33-13-14-34-15-16-35-25-22(29)17-3-1-2-4-18(17)23(25)30/h1-4H,5-16H2
• InChIKey: HLAGLPXQSIDIDX-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCON2C(=O)C3=CC=CC=C3C2=O

NHPI-PEG4-C2-NHS ester（Cat No.:I017760） serves as a linker in the construction of antibody-drug conjugates (ADCs). It is utilized to covalently attach small molecule drugs to antibodies, enabling targeted drug delivery. With a PEG4 spacer and an NHS ester moiety, the NHPI-PEG4-C2-NHS ester offers stability, water solubility, and controlled release of the drug payload. This linker allows for precise conjugation between the antibody and the drug, enhancing the therapeutic efficacy and reducing off-target effects of ADCs in the treatment of various diseases, including cancer.

Reference

[1]. Shailaja SRINAGESH, et al. Novel polypeptide small molecule conjugates and their uses