NHS-SS-biotin

• CAT Number: I016111
• CAS Number: 122266-55-1
• Molecular Formula: C₁₉H₂₈N₄O₆S₃
• Molecular Weight: 504.64
• Purity: ≥95%
• Target: ADC Linker
• Storage: 0-6°C
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethyldisulfanyl]propanoate
• InChI: InChI=1S/C19H28N4O6S3/c24-14(4-2-1-3-13-18-12(11-30-13)21-19(28)22-18)20-8-10-32-31-9-7-17(27)29-23-15(25)5-6-16(23)26/h12-13,18H,1-11H2,(H,20,24)(H2,21,22,28)/t12-,13-,18-/m0/s1
• InChIKey: LBEDTGQHCFODEH-LXIYXOSZSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCSSCCNC(=O)CCCCC2C3C(CS2)NC(=O)N3

NHS-SS-biotin（Cat No.:I016111） is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). It contains a disulfide bond that can be selectively cleaved under certain conditions, allowing for the release of the attached drug payload from the antibody. This linker provides a strategy for controlled drug release at the target site, enhancing the therapeutic potential of ADCs.

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.