For research use only. Not for therapeutic Use.
NIC3 (Cat No.: I018991) is a small-molecule inhibitor targeting the Notch signaling pathway, which plays a critical role in cell fate determination, differentiation, and proliferation. By modulating Notch receptor activity, NIC3 has been studied for its potential to suppress tumor growth and influence stem cell behavior. It is particularly relevant in cancer research, where aberrant Notch signaling is implicated in various malignancies. NIC3 helps elucidate the role of Notch in oncogenesis and tissue development, serving as a valuable tool in therapeutic target validation and drug discovery.
| CAS Number | 494830-67-0 |
| Molecular Formula | C₂₆H₃₆N₂O₄ |
| Purity | ≥95% |
| IUPAC Name | 2-(4-tert-butylphenoxy)-N-[2-[[2-(4-tert-butylphenoxy)acetyl]amino]ethyl]acetamide |
| InChI | 1S/C26H36N2O4/c1-25(2,3)19-7-11-21(12-8-19)31-17-23(29)27-15-16-28-24(30)18-32-22-13-9-20(10-14-22)26(4,5)6/h7-14H,15-18H2,1-6H3,(H,27,29)(H,28,30) |
| InChIKey | ZVSHISOEPMAPLF-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC=C(C=C1)OCC(=O)NCCNC(=O)COC2=CC=C(C=C2)C(C)(C)C |
| Reference | [1]. Wang X, et al. Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents. J Biol Chem. 2019 May 17. pii: jbc.RA119.007664. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
