For research use only. Not for therapeutic Use.
Nicainoprol（Cat No.: I004821）, is a potent antiarrhythmic agent known for its rapid sodium-channel blocking properties. It is employed in the management of cardiac arrhythmias, helping to restore and maintain normal heart rhythms by inhibiting abnormal electrical impulses in the heart. This compound’s ability to modulate sodium channels makes it valuable in treating conditions such as ventricular tachycardia and atrial fibrillation.
| Catalog Number | I004821 |
| CAS Number | 76252-06-7 |
| Molecular Formula | C21H27N3O3 |
| Purity | ≥95% |
| Target | Sodium Channel |
| Solubility | DMSO: ≥ 29 mg/mL |
| Storage | 2-8°C |
| IUPAC Name | [8-[2-hydroxy-3-(propan-2-ylamino)propoxy]-3,4-dihydro-2H-quinolin-1-yl]-pyridin-3-ylmethanone |
| InChI | InChI=1S/C21H27N3O3/c1-15(2)23-13-18(25)14-27-19-9-3-6-16-8-5-11-24(20(16)19)21(26)17-7-4-10-22-12-17/h3-4,6-7,9-10,12,15,18,23,25H,5,8,11,13-14H2,1-2H3 |
| InChIKey | AUIHHZBJBKRDIE-UHFFFAOYSA-N |
| SMILES | CC(C)NCC(COC1=CC=CC2=C1N(CCC2)C(=O)C3=CN=CC=C3)O |
| Reference | </br>1:Dose-related antiarrhythmic effects of nicainoprol in patients with chronic ventricular arrhythmias–a double-blind, placebo-controlled, cross-over multicentre trial. Nicainoprol Study Group. Schneider W, Reifart N, Blaeser A, Ostrowski J, Kaltenbach M, Kober G.Eur Heart J. 1991 Aug;12(8):900-8. PMID: 1915428 </br>2:Electrophysiological effects of nicainoprol in patients with paroxysmal supraventricular tachycardias. Sen S, Rettig G, Heisel A, Ozbek C, Schieffer H.Int J Cardiol. 1990 Nov;29(2):221-7. PMID: 2269541 </br>3:Modelling frequency- and voltage-dependent effects of a class I antiarrhythmic drug (nicainoprol) on Vmax of the cardiac action potential from guinea-pig papillary muscle. Weirich J, Antoni H.Naunyn Schmiedebergs Arch Pharmacol. 1989 Oct;340(4):456-64. PMID: 2586635 </br>4:Electrophysiologic effects of nicainoprol, a putative class I antiarrhythmic agent, on the guinea pig ventricular papillary muscle. Kimura T, Imanishi S, Arita M.J Cardiovasc Pharmacol. 1989 May;13(5):767-73. PMID: 2472526 </br>5:Antiarrhythmic effect of a new class 1 antiarrhythmic drug, nicainoprol, on canine ventricular arrhythmias. Hashimoto K, Akiyama K, Mitsuhashi H.Jpn J Pharmacol. 1989 Feb;49(2):245-54. PMID: 2733262 Free Article</br>6:Evaluation and interpretation of voltage- and frequency-dependent electrophysiologic effects of a new class I antiarrhythmic agent (nicainoprol) on guinea pig papillary muscle and isolated heart. Weirich J, Antoni H.J Cardiovasc Pharmacol. 1988 Dec;12(6):664-71. PMID: 2467084 </br>7:[Dose-related effect of nicainoprol (CAS 924) on basic electrophysiologic parameters in patients with and without diseases of the heart conduction system]. Sen S, Rettig G, Schieffer H, Bette L.Z Kardiol. 1988 Sep;77(9):600-7. German. PMID: 3195179 </br>8:Electrophysiological effects of intravenous nicaïnoprol, a new antiarrhythmic agent, in 11 patients. Libersa CC, Caron JF, Kacet S, Dagano J, Vincent A, Dupuis B, Gayet JL, Lekieffre JP.Eur Heart J. 1988 Mar;9(3):271-8. PMID: 3383868 </br>9:Effects of nicainoprol on reperfusion arrhythmia in the isolated working rat heart and on ischemia and reperfusion arrhythmia and myocardial infarct size in the anesthetized rat. Martorana PA, Linz W, Göbel H, Petry P, Schölkens BA.Eur J Pharmacol. 1987 Nov 17;143(3):391-401. PMID: 3691662 </br>10:Disposition kinetics and dynamics of nicainoprol, a new antiarrhythmic agent, in humans. Ishizaki T, Horai Y, Kubota K, Minegishi A, Echizen H, Chiba K.Clin Pharmacol Ther. 1987 Nov;42(5):525-34. PMID: 3677541 |
