Nicaraven

• CAT Number: A000169
• CAS Number: 79455-30-4
• Molecular Formula: C15H16N4O2
• Molecular Weight: 284.31
• Purity: ≥95%
• Synonyms: 79455-30-4; N,N/’-(Propane-1,2-diyl)dinicotinamide; 1,2-Bis(nicotinamido)propane; Nicaravenum [INN-Latin]; CCRIS 7280
• Storage: Desiccate at RT
• InChI: 1S/C15H16N4O2/c1-11(19-15(21)13-5-3-7-17-10-13)8-18-14(20)12-4-2-6-16-9-12/h2-7,9-11H,8H2,1H3,(H,18,20)(H,19,21)
• InChIKey: KTXBOOWDLPUROC-UHFFFAOYSA-N
• SMILES: CC(CNC(=O)C1=CN=CC=C1)NC(=O)C2=CN=CC=C2

Nicaraven is a hydroxyl radical scavenger with antivasospastic and neuroprotective effects.

Reference

1: Yan C, Luo L, Urata Y, Goto S, Guo CY, Li TS. Nicaraven, a Potential
Radioprotective Agent, has Very Limited Effects on the Survival of Cancer Cells
and the Growth of Established Tumors. Radiat Res. 2017 Mar;187(3):339-345. doi:
10.1667/RR4614.1. PubMed PMID: 28326999.

2: Yan C, Luo L, Urata Y, Goto S, Guo CY, Li TS. Nicaraven, a Potential
Radioprotective Agent, has Very Limited Effects on the Survival of Cancer Cells
and the Growth of Established Tumors. Radiat Res. 2017 Feb 22. doi:
10.1667/RR14614.1. [Epub ahead of print] PubMed PMID: 28225650.

3: Ali H, Galal O, Urata Y, Goto S, Guo CY, Luo L, Abdelrahim E, Ono Y, Mostafa
E, Li TS. The potential benefits of nicaraven to protect against
radiation-induced injury in hematopoietic stem/progenitor cells with relative low
dose exposures. Biochem Biophys Res Commun. 2014 Sep 26;452(3):548-53. doi:
10.1016/j.bbrc.2014.08.112. Epub 2014 Aug 28. PubMed PMID: 25173934.

4: Kawakatsu M, Urata Y, Imai R, Goto S, Ono Y, Nishida N, Li TS. Nicaraven
attenuates radiation-induced injury in hematopoietic stem/progenitor cells in
mice. PLoS One. 2013;8(3):e60023. doi: 10.1371/journal.pone.0060023. Epub 2013
Mar 29. PubMed PMID: 23555869; PubMed Central PMCID: PMC3612087.

5: Shimada Y, Tsunoda H, Zang L, Hirano M, Oka T, Tanaka T. Synergistic induction
of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed
cerebral vasospasm. Eur J Pharmacol. 2009 Oct 12;620(1-3):16-20. doi:
10.1016/j.ejphar.2009.08.009. Epub 2009 Aug 15. PubMed PMID: 19686725.

6: Watanabe M, Akiyama N, Sekine H, Mori M, Manome Y. Inhibition of poly
(ADP-ribose) polymerase as a protective effect of nicaraven in ionizing
radiation- and ara-C-induced cell death. Anticancer Res. 2006
Sep-Oct;26(5A):3421-7. PubMed PMID: 17094462.

7: Yoshinaga H, Watanabe M, Manome Y. Possible role of nicaraven in
neuroprotective effect on hippocampal slice culture. Can J Physiol Pharmacol.
2003 Jul;81(7):683-9. PubMed PMID: 12897815.

8: Leker RR. Nicaraven Chugai. Curr Opin Investig Drugs. 2003 Jan;4(1):83-90.
Review. PubMed PMID: 12625035.

9: Jain KK. Nicaraven for the treatment of cerebral vasospasm in subarachnoid
haemorrhage. Expert Opin Investig Drugs. 2000 Apr;9(4):859-70. Review. PubMed
PMID: 11060715.

10: Yokota R, Fukai M, Shimamura T, Suzuki T, Watanabe Y, Nagashima K, Kishida A,
Furukawa H, Hayashi T, Todo S. A novel hydroxyl radical scavenger, nicaraven,
protects the liver from warm ischemia and reperfusion injury. Surgery. 2000
Jun;127(6):661-9. PubMed PMID: 10840362.