For research use only. Not for therapeutic Use.
Nicardipine (Cat No.: I004092), also known as Pell and Nifedipine, is a second-generation dihydropyridine calcium channel blocker. Is a new calcium antagonist. It is clinically used for cerebrovascular congestion, sequelae of cerebral hemorrhage and cerebral steatosis. Treatment of essential hypertension, sudden deafness, etc.
| Catalog Number | I004092 |
| CAS Number | 55985-32-5 |
| Molecular Formula | C26H29N3O6 |
| Purity | ≥95% |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| InChI | InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3 |
| InChIKey | ZBBHBTPTTSWHBA-UHFFFAOYSA-N |
| SMILES | CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC |
| Reference | </br>1:Paradoxical cerebrovascular hemodynamic changes with nicardipine. Lahiri S, Nezhad M, Schlick KH, Rinsky B, Rosengart A, Mayer SA, Lyden PD.J Neurosurg. 2017 Apr 21:1-5. doi: 10.3171/2016.11.JNS161992. [Epub ahead of print] PMID: 28430036 </br>2:Rifampicin reverses nicardipine effect inducing uncontrolled essential hypertension. Cordeanu EM, Gaertner S, Faller A, Mirea C, Lessinger JM, Kemmel V, Stephan D.Fundam Clin Pharmacol. 2017 Apr 13. doi: 10.1111/fcp.12292. [Epub ahead of print] PMID: 28407303 </br>3:Effectiveness of intrathecal nicardipine on cerebral vasospasm in non-traumatic subarachnoid hemorrhage: a systematic review protocol. Stuart D, Christian R, Uschmann H.JBI Database System Rev Implement Rep. 2017 Mar;15(3):628-637. doi: 10.11124/JBISRIR-2016-002962. PMID: 28267024 </br>4:The effect of nicardipine on the surgical pleth index during thyroidectomy under general anesthesia: A prospective double-blind randomized controlled trial. Won YJ, Lim BG, Yeo GE, Lee MK, Lee DK, Kim H, Lee IO, Kong MH.Medicine (Baltimore). 2017 Feb;96(6):e6154. doi: 10.1097/MD.0000000000006154. PMID: 28178175 Free PMC Article</br>5:Clevidipine Versus Nicardipine for Acute Blood Pressure Reduction in a Neuroscience Intensive Care Population. Finger JR, Kurczewski LM, Brophy GM.Neurocrit Care. 2017 Apr;26(2):167-173. doi: 10.1007/s12028-016-0349-4. PMID: 27995512 </br>6:Angiotensin II receptor blockers following intravenous nicardipine administration to lower blood pressure in patients with hypertensive intracerebral hemorrhage: a prospective randomized study. Inamasu J, Nakae S, Adachi K, Hirose Y.Blood Press Monit. 2017 Feb;22(1):34-39. doi: 10.1097/MBP.0000000000000225. PMID: 27824680 </br>7:Risk Factors of Nicardipine-Related Phlebitis in Acute Stroke Patients. Kawada K, Ohta T, Tanaka K, Kadoguchi N, Yamamoto S, Morimoto M.J Stroke Cerebrovasc Dis. 2016 Oct;25(10):2513-8. doi: 10.1016/j.jstrokecerebrovasdis.2016.06.028. Epub 2016 Jul 14. PMID: 27423368 </br>8:Reducing Cost and Intravenous Duration of Nicardipine in Intracerebral Hemorrhage Patients via an Interdisciplinary Approach. Shah NH, Do LV, Petrovich J, Crozier K, Azran C, Josephson SA.J Stroke Cerebrovasc Dis. 2016 Sep;25(9):2290-4. doi: 10.1016/j.jstrokecerebrovasdis.2016.05.021. Epub 2016 Jun 14. PMID: 27315743 </br>9:Effects of nicardipine on the onset time and intubation conditions of rocuronium-induced neuromuscular blockade. Lee SY, Kim YH, Ko YK, Park SI, Lee JU, Chung WS, Lim CS.J Clin Anesth. 2016 Aug;32:112-8. doi: 10.1016/j.jclinane.2016.02.010. Epub 2016 Apr 20. PMID: 27290958 </br>10:Nicardipine Effects on Renal Function During Spine Surgery. Park C, Kim JY, Kim C, Chang CH.Clin Spine Surg. 2016 May 27. [Epub ahead of print] PMID: 27231835 |
