For research use only. Not for therapeutic Use.
Niclofolan（Cat No.:M063946）is an antiparasitic drug primarily used to treat infections caused by liver flukes and other trematodes in animals. Its mechanism targets the metabolic pathways of parasitic worms, disrupting their energy production and leading to their elimination. Niclofolan’s efficacy in single-dose treatments makes it a practical choice for managing parasitic infections in livestock, minimizing animal stress and simplifying treatment protocols. Known for its broad-spectrum activity, it supports animal health and productivity by controlling fluke infestations, which can cause significant damage to liver function and overall livestock well-being.
| Catalog Number | M063946 |
| CAS Number | 10331-57-4 |
| Molecular Formula | C12H6Cl2N2O6 |
| Purity | ≥95% |
| Storage | Store at +4C |
| IUPAC Name | 4-chloro-2-(5-chloro-2-hydroxy-3-nitrophenyl)-6-nitrophenol |
| InChI | InChI=1S/C12H6Cl2N2O6/c13-5-1-7(11(17)9(3-5)15(19)20)8-2-6(14)4-10(12(8)18)16(21)22/h1-4,17-18H |
| InChIKey | XULACPAEUUWKFX-UHFFFAOYSA-N |
| SMILES | C1=C(C=C(C(=C1[N+](=O)[O-])O)C2=CC(=CC(=C2O)[N+](=O)[O-])Cl)Cl |
| Reference | </br>1:Pharmacokinetics of niclofolan in desert sheep. Ali BH, el Sheikh HA, McKellar QA.J Vet Pharmacol Ther. 1990 Jun;13(2):217-9. No abstract available. PMID: 2384912 </br>2:The effect of niclofolan on desert sheep experimentally infected with immature Fasciola gigantica. Ali BH, Hassan T, Haroun EM, Abu Samra MT.J Vet Pharmacol Ther. 1985 Dec;8(4):398-403. PMID: 4094030 </br>3:Trematodiasis in Turkey: comparative efficacy of triclabendazole and niclofolan against natural infections of Fasciola hepatica and F. gigantica in sheep. Güralp N, Tinar R.J Helminthol. 1984 Jun;58(2):113-6. PMID: 6747253 </br>4:[Anthelmintic activity of niclofolan and closantel against Fasciola hepatica in sheep]. González H, Plaza J, Montes G, Pérez R, Toro P.Bol Chil Parasitol. 1983 Jul-Dec;38(3-4):42-9. Spanish. No abstract available. PMID: 6375690 </br>5:Cholestatic jaundice in fascioliasis treated with niclofolan. Reshef R, Lok AS, Sherlock S.Br Med J (Clin Res Ed). 1982 Oct 30;285(6350):1243-4. No abstract available. PMID: 6812826 Free PMC Article</br>6:A Case Of Niclofolan (Bilevon(R)) Intoxication. Hong ST, Lee SH, Ahn HS, Yun CK.Kisaengchunghak Chapchi. 1982 Jun;20(1):49-52. PMID: 12902700 Free Article</br>7:Treatment of human fascioliasis with niclofolan. Eckhardt T, Heckers H.Gastroenterology. 1981 Oct;81(4):795-8. PMID: 7262525 </br>8:[Epidemiologic and clinical study of paragonimosis in Cameroon. Results of niclofolan treatment]. Ripert C, Carrie J, Ambroise-Thomas P, Baecher R, Kum NP, Same-Ekobo A.Bull Soc Pathol Exot Filiales. 1981 May-Jun;74(3):319-31. French. PMID: 7285268 </br>9:Studies on the chemotherapy of human opisthorchiasis: II. Clinical trial of niclofolan. Bunnag D, Harinasuta T, Desakorn V.Southeast Asian J Trop Med Public Health. 1981 Mar;12(1):107-9. PMID: 7020093 </br>10:[Preliminary observation on the treatment of paragonimiasis westermani (thoracic type) with domestic niclofolan in 26 cases (author/’s transl)]. Cao WJ.Zhonghua Nei Ke Za Zhi. 1980 May;19(3):226-9. Chinese. No abstract available. PMID: 7227061 |
