Niclosamide monohydrate

For research use only, not for therapeutic use.

  • CAT Number: I004728
  • CAS Number: 73360-56-2
  • Molecular Formula: C13H10Cl2N2O5
  • Molecular Weight: 345.13
  • Purity: ≥95%
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Niclosamide Monohydrate(BAY2353 monohydrate) is used for the treatment of most tapeworm infections by inhibiting DNA replication.<br />
Target: Antiparasitic<br />
Niclosamide (&lt; 5 &mu;M) dose dependently inhibits STAT3-mediated luciferase reporter activity with IC50 of 0.25 &mu;M in HeLa cells. Niclosamide(&lt; 2 &mu;M) dose dependently inhibits the phosphorylation of STAT3 in Du145 cells. Niclosamide (1 &mu;M) inhibits the EGF-induced nuclear translocation of STAT3 in Du145 cells. Niclosamide(&lt; 2 &mu;M) dose dependently inhibits the transcription of STAT3 downstream genes in Du145 cells. Niclosamide(&lt; 10 &mu;M) dose dependently induces G0/G1 arrest and apoptosis of Du145 cancer cells [1]. Niclosamide(&lt; 7.5 &mu;M) promotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein, and inhibits Wnt3A-stimulated beta-catenin stabilization and LEF/TCF reporter activity in U2OS cells [2]. Niclosamide inhibits the TNF-induced NF-&kappa;B reporter activity in a dose- and time-dependent manner in U2OS cells. Niclosamide(125 nM) inhibits NF-&kappa;B activation induced by p65, IKK&alpha;, IKK&beta;, IKK&gamma;, and TAK1 in U2OS cells. Niclosamide(&lt; 500 nM) completely block the time- and dose-dependent TNF&alpha;-induced alteration of the NF-&kappa;B-DNA complex in HL-60 cells. Niclosamide(&lt; 10 nM) inhibits constitutive NF-&kappa;B activation in U266 cells. Niclosamide inhibits TNF-induced degradation of I&kappa;B&alpha; and relocation of p65 in a dose- and time-dependent manner in HL-60, Molm13, or AML primary cells. Niclosamide(500 nM) decreases TNF-induced NF-&kappa;B-dependent gene products involved in cell survival in HL-60 cells. Niclosamide dose dependently inhibits the growth and induces robust apoptosis of AML cells associated with decreased Mcl-1 and XIAP levels and increased intracellular ROS levels [3].</p>


Catalog Number I004728
CAS Number 73360-56-2
Synonyms

5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide;hydrate

Molecular Formula C13H10Cl2N2O5
Purity ≥95%
Target Antibiotic
Solubility 10 mM in DMSO
Storage Store at -20C
IUPAC Name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide;hydrate
InChI InChI=1S/C13H8Cl2N2O4.H2O/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15;/h1-6,18H,(H,16,19);1H2
InChIKey ZBXRPLQCPHTHLM-UHFFFAOYSA-N
SMILES C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O.O
Reference

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[1]. Ren, X., et al., Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signaling pathway. ACS Medicinal Chemistry Letters, 2010. 1(9): p. 454-459.<br />
[2]. Chen, M., et al., The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry, 2009. 48(43): p. 10267-74.<br />
[3]. Jin, Y., et al., Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res, 2010. 70(6): p. 2516-27.</p>

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