NICOTINAMIDE RIBOSIDE

• CAT Number: M048432
• CAS Number: 1341-23-7
• Molecular Formula: C₁₁H₁₅N₂O₅⁺
• Molecular Weight: 255.25
• Purity: ≥95%
• Synonyms: 3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium; Nicotinamide ribonucleoside; Nicotinamide ribose
• Storage: Desiccate at +4C
• IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide
• InChI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1
• InChIKey: JLEBZPBDRKPWTD-TURQNECASA-O
• SMILES: C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N

Nicotinamide riboside (NR)（Cat No.:M048432）is a naturally occurring form of vitamin B3 and a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in cellular metabolism and energy production. Research suggests that NR can enhance NAD+ levels, potentially improving mitochondrial function and promoting healthy aging. Its benefits extend to metabolic health, neuroprotection, and enhancing exercise performance. Studies are ongoing to explore its therapeutic potential in age-related diseases, neurodegenerative disorders, and metabolic conditions, positioning nicotinamide riboside as a promising candidate for dietary supplementation and innovative health interventions.

Reference

1. Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):657-61. doi: 10.1097/MCO.0b013e32836510c0.
Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.
Chi Y(1), Sauve AA.
Author information:
(1)aDepartment of Medicine, Albert Einstein College of Medicine, Bronx bDepartment of Pharmacology, Weill Cornell Medical College, New York, New York, USA.
PURPOSE OF REVIEW: This review focuses upon the biology and metabolism of a trace component in foods called nicotinamide riboside. Nicotinamide riboside is a precursor of nicotinamide adenine dinucleotide (NAD), and is a source of Vitamin B3. Evidence indicates that nicotinamide riboside has unique properties as a Vitamin B3. We review knowledge of the metabolism of this substance, as well as recent work suggesting novel health benefits that might be associated with nicotinamide riboside taken in larger quantities than is found naturally in foods.
RECENT FINDINGS: Recent work investigating the effects of nicotinamide riboside in yeast and mammals established that it is metabolized by at least two types of metabolic pathways. The first of these is degradative and produces nicotinamide. The second pathway involves kinases called nicotinamide riboside kinases (Nrk1 and Nrk2, in humans). The likely involvement of the kinase pathway is implicated in the unique effects of nicotinamide riboside in raising tissue NAD concentrations in rodents and for potent effects in eliciting insulin sensitivity, mitochondrial biogenesis, and enhancement of sirtuin functions. Additional studies with nicotinamide riboside in models of Alzheimer/'s disease indicate bioavailability to brain and protective effects, likely by stimulation of brain NAD synthesis.
SUMMARY: Initial studies have clarified the potential for a lesser-known Vitamin B3 called nicotinamide riboside that is available in selected foods, and possibly available to humans by supplements. It has properties that are insulin sensitizing, enhancing to exercise, resisting to negative effects of high-fat diet, and neuroprotecting.
2. Annu Rev Nutr. 2008;28:115-30. doi: 10.1146/annurev.nutr.28.061807.155443.
Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.
Bogan KL(1), Brenner C.
Author information:
(1)Department of Genetics and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.
Although baseline requirements for nicotinamide adenine dinucleotide (NAD+) synthesis can be met either with dietary tryptophan or with less than 20 mg of daily niacin, which consists of nicotinic acid and/or nicotinamide, there is growing evidence that substantially greater rates of NAD+ synthesis may be beneficial to protect against neurological degeneration, Candida glabrata infection, and possibly to enhance reverse cholesterol transport. The distinct and tissue-specific biosynthetic and/or ligand activities of tryptophan, nicotinic acid, nicotinamide, and the newly identified NAD+ precursor, nicotinamide riboside, reviewed herein, are responsible for vitamin-specific effects and side effects. Because current data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis, we present prospects for human nicotinamide riboside supplementation and propose areas for future research.