Nicotinamide riboside malate

• CAT Number: E000030
• CAS Number: 2415659-01-5
• Molecular Formula: C15H20N2O10
• Molecular Weight: 388.33
• Purity: ≥95%
• Synonyms: Nicotinamide riboside malate
• IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide;(3S)-3,4-dihydroxy-4-oxobutanoate
• InChI: InChI=1S/C11H14N2O5.C4H6O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11;5-2(4(8)9)1-3(6)7/h1-4,7-9,11,14-16H,5H2,(H-,12,17);2,5H,1H2,(H,6,7)(H,8,9)/t7-,8-,9-,11-;2-/m10/s1
• InChIKey: CCIJCSINBFLRRP-FFHQWVQZSA-N
• SMILES: C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N.C([C@@H](C(=O)O)O)C(=O)[O-]

Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.