Nifuratel

• CAT Number: I003734
• CAS Number: 4936-47-4
• Molecular Formula: C10H11N3O5S
• Molecular Weight: 285.28
• Purity: ≥95%
• Synonyms: 5-(methylsulfanylmethyl)-3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one
• Target: Bacterial
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 0.125-1 μg/mL(MIC, A. vaginae) [1]
• InChI: InChI=1S/C10H11N3O5S/c1-19-6-8-5-12(10(14)18-8)11-4-7-2-3-9(17-7)13(15)16/h2-4,8H,5-6H2,1H3/b11-4+
• InChIKey: SRQKTCXJCCHINN-NYYWCZLTSA-N
• SMILES: CSCC1CN(C(=O)O1)/N=C/C2=CC=C(O2)[N+](=O)[O-]

Nifuratel（Cat No.:I003734）is a synthetic nitrofuran-derived antimicrobial agent with broad-spectrum activity against bacteria, fungi, and protozoa, making it versatile in treating infections such as vaginal, urinary tract, and gastrointestinal infections. It disrupts microbial cellular processes, leading to cell death, and is particularly valued for its efficacy against Trichomonas vaginalis, Candida species, and Giardia lamblia. Nifuratel’s favorable safety profile and low resistance rate make it a preferred choice for treating mixed infections in gynecological and urological settings, with applications extending to research on multi-target antimicrobial therapies.

Reference

[1]. Polatti F. Bacterial vaginosis, Atopobium vaginae and nifuratel. Curr Clin Pharmacol. 2012 Feb 1;7(1):36-40.

[2]. Nijevitch AA, et al. Helicobacter pylori eradication in childhood after failure of initial treatment: advantage of quadruple therapy withnifuratel to furazolidone. Aliment Pharmacol Ther. 2005 Nov 1;22(9):881-7.

[3]. Nijevitch AA, et al. Nifuratel-containing initial anti-Helicobacter pylori triple therapy in children. Helicobacter. 2007 Apr;12(2):132-5.