For research use only. Not for therapeutic Use.
Nigericin is an antibiotic derived from Streptomyces hygroscopicus. Its isolation was described in the 1950s,[1] and in 1968 the structure could be elucidated by X-ray crystallography. The structure and properties of nigericin are similar to the antibiotic monensin. Commercially it is obtained as a byproduct, or contaminant, at the fermentation of Geldanamycin. It is also called Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464. Nigericin acts as an H+, K+, Pb2+ ionophore. Most commonly it is an antiporter of H+ and K+. In the past nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions in Eukaryotic cells. Nigericin exhibits anticancer and anti-HIV activity.
| Catalog Number | I008178 |
| CAS Number | 28380-24-7 |
| Synonyms | Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A;sodium (R)-2-((2R,3S,6R)-6-(((2S,4R,5R,7R,9R,10R)-2-((2S,2/’R,3/’S,5R,5/’R)-5/’-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,3/’-dimethyloc |
| Molecular Formula | C40H68O11 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| Reference | </br>1:[Kinetic properties of sodium transport pathways in the river lamprey Lampetra fluviatilis erythrocytes]. Ivanova TI, Sherstobitov AO, Gusev GP.Zh Evol Biokhim Fiziol. 2007 Nov-Dec;43(6):468-73. Russian. PMID: 18265557 </br>2:Amiloride-sensitive sodium transport in lamprey red blood cells: evidence for two distinct transport pathways. Gusev GP, Ivanova TI.Gen Physiol Biophys. 2004 Dec;23(4):443-56. PMID: 15815079 Free Article</br>3:Platelet sodium-hydrogen exchanger activity and left ventricular mass. Khong TK, Sagnella GA, Markandu ND, Miller MA, Missouris CG, MacGregor GA.J Hum Hypertens. 2001 Aug;15(8):523-7. PMID: 11494089 Free Article</br>4:Platelet sodium/hydrogen exchanger activity in normotensives and hypertensives. Sagnella GA, Miller MA, Khong TK, MacGregor GA.Clin Chim Acta. 1999 May;283(1-2):105-18. PMID: 10404735 </br>5:Novel benzamil-sensitive sodium-independent choline transport in the cestode Hymenolepis diminuta: evidence for sodium channels uptake at low pH. Xue L, Webb RA.Comp Biochem Physiol A Physiol. 1997 Dec;118(4):1173-81. PMID: 9505427 </br>6:The influence of ascorbic acid on active sodium transport in cultured rabbit nonpigmented ciliary epithelium. Hou Y, Pierce WM Jr, Delamere NA.Invest Ophthalmol Vis Sci. 1998 Jan;39(1):143-50. PMID: 9430555 </br>7:Characterization of sodium-calcium exchange in rabbit renal arterioles. Fowler BC, Carmines PK, Nelson LD, Bell PD.Kidney Int. 1996 Dec;50(6):1856-62. PMID: 8943467 Free Article</br>8:The sodium-calcium antiport of heart mitochondria is not electroneutral. Jung DW, Baysal K, Brierley GP.J Biol Chem. 1995 Jan 13;270(2):672-8. PMID: 7822294 Free Article</br>9:Determination of semduramicin sodium in poultry liver by liquid chromatography with vanillin postcolumn derivatization. Ericson JF, Calcagni A, Lynch MJ.J AOAC Int. 1994 May-Jun;77(3):577-82. PMID: 8012203 </br>10:Sodium-dependent antiporters in choroid plexus epithelial cultures from rabbit. Mayer SE, Sanders-Bush E.J Neurochem. 1993 Apr;60(4):1308-16. PMID: 8384246 |
