Nigericin sodium

• CAT Number: I008178
• CAS Number: 28380-24-7
• Molecular Formula: C40H68O11
• Molecular Weight: 724.96
• Purity: ≥95%
• Synonyms: Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A;sodium (R)-2-((2R,3S,6R)-6-(((2S,4R,5R,7R,9R,10R)-2-((2S,2/’R,3/’S,5R,5/’R)-5/’-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,3/’-dimethyloc
• Target: Immunology/Inflammation
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid
• InChI: 1S/C40H68O11/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34/h21-35,41,44H,11-20H2,1-10H3,(H,42,43)/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+/m0/s1
• InChIKey: DANUORFCFTYTSZ-SJSJOXFOSA-N
• SMILES: C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)O)C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC

Nigericin sodium is a potassium ionophore and a selective antibiotic compound that facilitates the exchange of potassium and hydrogen ions across cellular membranes. It has been primarily used in scientific research to disrupt cellular ion gradients, leading to alterations in pH and membrane potential. Nigericin sodium is known for its ability to induce ion imbalances, making it useful in studying cellular processes such as membrane transport, mitochondrial function, and apoptosis. It also has potential applications in immunology and cancer research.