Nigericin sodium salt

• CAT Number: I002977
• CAS Number: 28643-80-3
• Molecular Formula: C40H67O11 • Na
• Molecular Weight: 746.94
• Purity: ≥95%
• Synonyms: NSC 292567
• Target: Immunology/Inflammation
• Solubility: 10 mM in ethanol, DMSO: ＜ 0.3 mg/mL, H2O: ＜ 0.3 mg/mL
• Storage: -20°C
• IUPAC Name: sodium;(2R)-2-[(2R,3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(2R,5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate
• InChI: 1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+;/m0./s1
• InChIKey: MOYOTUKECQMGHE-HOIKPYQJSA-M
• SMILES: C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)[O-])C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC.[Na+]

Nigericin sodium salt is an ionophore derived from Streptomyces hygroscopicus, widely used in research for its ability to exchange H⁺ (protons) and K⁺ (potassium ions) across biological membranes. It disrupts ion gradients, making it a valuable tool for studying mitochondrial function, intracellular pH regulation, and apoptosis. Nigericin is also utilized in experiments involving Golgi apparatus acidification and as a positive control in inflammasome activation studies. Its role in modulating ion transport pathways has made it essential in biochemical, pharmacological, and cell biology research.