For research use only. Not for therapeutic Use.
NIH-12848(CAT: I008180) is a compound that has been identified as a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ). PI5P4Kγ is an enzyme involved in the regulation of cellular signaling pathways by phosphorylating phosphatidylinositol 5-phosphate (PI5P) to generate phosphatidylinositol 4,5-bisphosphate (PIP2). Inhibition of PI5P4Kγ may modulate PIP2 levels and disrupt downstream signaling cascades.
| Catalog Number | I008180 |
| CAS Number | 959551-10-1 |
| Synonyms | NIH-12848; NIH 12848; NIH12848, NCGC00012848-02.;N-(thiophen-2-ylmethyl)-2-(2-(trifluoromethyl)phenyl)quinazolin-4-amine |
| Molecular Formula | C20H14F3N3S |
| Purity | ≥95% |
| Target | PI5P4K |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| InChI | InChI=1S/C20H14F3N3S/c21-20(22,23)16-9-3-1-7-14(16)19-25-17-10-4-2-8-15(17)18(26-19)24-12-13-6-5-11-27-13/h1-11H,12H2,(H,24,25,26) |
| InChIKey | QBDAEJRHUCSSPR-UHFFFAOYSA-N |
| SMILES | FC(F)(F)C(C=CC=C1)=C1C2=NC3=CC=CC=C3C(NCC4=CC=CS4)=N2 |
| Reference | </br>1:Clarke JH, Giudici ML, Burke JE, Williams RL, Maloney DJ, Marugan J, Irvine RF. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Biochem J. 2015 Mar 1;466(2):359-67. doi: 10.1042/BJ20141333. PubMed PMID: 25495341; PubMed Central PMCID: PMC4687057. |
