Nimustine hydrochloride

• CAT Number: I014525
• CAS Number: 55661-38-6
• Molecular Formula: C9H14Cl2N6O2
• Molecular Weight: 309.15
• Purity: ≥95%
• Synonyms: CS 439 HCl; CS439 HCl; CS-439 HCl; CS-439; CS439; CS 439;Urea, N’-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitroso-, monohydrochloride (9CI)
• Solubility: Soluble in DMSO
• Storage: 2–8 °C
• IUPAC Name: 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-nitrosourea;hydrochloride
• InChI: InChI=1S/C9H13ClN6O2.ClH/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10;/h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14);1H
• InChIKey: KPMKNHGAPDCYLP-UHFFFAOYSA-N
• SMILES: CC1=NC=C(C(=N1)N)CNC(=O)N(CCCl)N=O.Cl

Nimustine hydrochloride (Cat No.:I014525) is a DNA cross-linking agent and DNA alkylating agent, which can induce DNA replication damage and DNA double-strand break, inhibit DNA synthesis, and is commonly used in the chemotherapy of glioblastoma. It has anti-tumor effect, degrades intracellular DNA by alkylation, and inhibits the synthesis of DNA and RNA.

Reference

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