Nimustine hydrochloride

• CAT Number: I014525
• CAS Number: 55661-38-6
• Molecular Formula: C9H14Cl2N6O2
• Molecular Weight: 309.15
• Purity: ≥95%
• Synonyms: CS 439 HCl; CS439 HCl; CS-439 HCl; CS-439; CS439; CS 439;Urea, N’-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(2-chloroethyl)-N-nitroso-, monohydrochloride (9CI)
• Target: Apoptosis
• Solubility: Soluble in DMSO
• Storage: 2–8 °C
• IUPAC Name: 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-nitrosourea;hydrochloride
• InChI: InChI=1S/C9H13ClN6O2.ClH/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10;/h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14);1H
• InChIKey: KPMKNHGAPDCYLP-UHFFFAOYSA-N
• SMILES: CC1=NC=C(C(=N1)N)CNC(=O)N(CCCl)N=O.Cl

Nimustine Hydrochloride（Cat No.:I014525）is a nitrosourea-class alkylating agent used in chemotherapy for treating brain tumors, malignant lymphomas, and other cancers. It works by crosslinking DNA strands and inhibiting DNA synthesis, leading to apoptosis in rapidly dividing cancer cells. Nimustine’s ability to penetrate the blood-brain barrier makes it particularly effective for central nervous system malignancies. It is also used in research to study DNA damage mechanisms and the development of chemoresistance. Nimustine Hydrochloride remains an essential tool in advancing cancer treatment and understanding alkylating agent pharmacodynamics.

Reference

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