For research use only. Not for therapeutic Use.
Nisoldipine (Cat No.:I004404) is a new dihydropyridine calcium blocker successfully studied by Wehinger et al. in 1977. For hypertension, heart failure, ischemic heart disease, angina pectoris, and abnormal angina pectoris, especially suitable for coronary heart disease combined with hypertension.
| Catalog Number | I004404 |
| CAS Number | 63675-72-9 |
| Synonyms | 3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| Molecular Formula | C20H24N2O6 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | DMSO > 70 mg/mL Ethanol > 70 mg/mL |
| Storage | room temp |
| IC50 | 10 nM |
| IUPAC Name | 3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| InChI | InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3 |
| InChIKey | VKQFCGNPDRICFG-UHFFFAOYSA-N |
| SMILES | CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC |
| Reference | </br>1:Comparative evaluation of proliposomes and self micro-emulsifying drug delivery system for improved oral bioavailability of nisoldipine. Nekkanti V, Rueda J, Wang Z, Betageri GV.Int J Pharm. 2016 May 30;505(1-2):79-88. doi: 10.1016/j.ijpharm.2016.03.065. Epub 2016 Mar 31. PMID: 27041124 </br>2:Optimization and development of Nisoldipine nano-bioenhancers by novel orthogonal array (L27 array). Rathee P, Kamboj A, Sidhu S.Int J Biol Macromol. 2016 May;86:556-61. doi: 10.1016/j.ijbiomac.2016.01.097. Epub 2016 Feb 1. PMID: 26845477 </br>3:Transdermal Delivery of Nisoldipine: Refinement of Vehicles. El Maghraby GM, Ahmed AA, Osman MA.Int J Pharm Compd. 2015 Mar-Apr;19(2):152-60. PMID: 26685495 </br>4:Investigating the role of nisoldipine in foot-shock-induced post-traumatic stress disorder in mice. Verma M, Bali A, Singh N, Jaggi AS.Fundam Clin Pharmacol. 2016 Apr;30(2):128-36. doi: 10.1111/fcp.12174. Epub 2016 Jan 18. PMID: 26662718 </br>5:Polymeric behavior evaluation of PVP K30-poloxamer binary carrier for solid dispersed nisoldipine by experimental design. Kyaw Oo M, Mandal UK, Chatterjee B.Pharm Dev Technol. 2017 Feb;22(1):2-12. doi: 10.3109/10837450.2015.1116568. Epub 2015 Nov 29. PMID: 26616399 </br>6:Investigating the in vitro stereoselective metabolism of m-nisoldipine enantiomers: characterization of metabolites and cytochrome P450 isoforms involved. Sun Y, Jia P, Yuan L, Liu Y, Zhang Z, Du Y, Zhang L.Biomed Chromatogr. 2015 Dec;29(12):1893-900. doi: 10.1002/bmc.3512. Epub 2015 Jun 29. PMID: 25994315 </br>7:Pharmacokinetic and pharmacodynamic studies of nisoldipine-loaded solid lipid nanoparticles developed by central composite design. Dudhipala N, Veerabrahma K.Drug Dev Ind Pharm. 2015;41(12):1968-77. doi: 10.3109/03639045.2015.1024685. Epub 2015 Apr 1. PMID: 25830370 </br>8:Study of in vitro metabolism of m-nisoldipine in human liver microsomes and recombinant cytochrome P450 enzymes by liquid chromatography-mass spectrometry. Yuan L, Jia P, Sun Y, Zhao C, Zhi X, Sheng N, Zhang L.J Pharm Biomed Anal. 2014 Aug;97:65-71. doi: 10.1016/j.jpba.2014.03.030. Epub 2014 Mar 28. PMID: 24816159 </br>9:Studies on separation and pharmacokinetics of m-nisoldipine enantiomers in beagle dog plasma by LC/MS/MS. Li M, Yuan L, Li X, Zhi X, Sheng N, Zhang L.J Pharm Biomed Anal. 2013 Nov;85:61-6. doi: 10.1016/j.jpba.2013.06.015. Epub 2013 Jul 10. PMID: 23892657 </br>10:Fast disintegrating tablets of nisoldipine for intra-oral administration. El Maghraby GM, Elsergany RN.Pharm Dev Technol. 2014 Sep;19(6):641-50. doi: 10.3109/10837450.2013.813543. Epub 2013 Jul 10. PMID: 23841582 |
