For research use only. Not for therapeutic Use.
NITD-2, a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly[1].
NITD-2 inhibits de novo RNA synthesis[1].
NITD-2 exhibited no antiviral activity in cell culture resulted from the poor cell penetratration[1].
| Catalog Number | I033343 |
| CAS Number | 1197896-79-9 |
| Synonyms | 2-[[3-(1-benzylpyrazol-4-yl)phenyl]sulfonylamino]benzoic acid |
| Molecular Formula | C23H19N3O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C23H19N3O4S/c27-23(28)21-11-4-5-12-22(21)25-31(29,30)20-10-6-9-18(13-20)19-14-24-26(16-19)15-17-7-2-1-3-8-17/h1-14,16,25H,15H2,(H,27,28) |
| InChIKey | PHQOBFYGHBBCBV-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CN2C=C(C=N2)C3=CC(=CC=C3)S(=O)(=O)NC4=CC=CC=C4C(=O)O |
| Reference | [1]. Pornwaratt Niyomrattanakit, et al. Inhibition of dengue virus polymerase by blocking of the RNA tunnel. J Virol. 2010 Jun;84(11):5678-86. |
