Nitracrine

• CAT Number: I013284
• CAS Number: 4533-39-5
• Molecular Formula: C18H20N4O2
• Molecular Weight: 324.38
• Purity: ≥95%
• Synonyms: N’,N’-dimethyl-N-(1-nitroacridin-9-yl)propane-1,3-diamine
• IUPAC Name: N',N'-dimethyl-N-(1-nitroacridin-9-yl)propane-1,3-diamine
• InChI: InChI=1S/C18H20N4O2/c1-21(2)12-6-11-19-18-13-7-3-4-8-14(13)20-15-9-5-10-16(17(15)18)22(23)24/h3-5,7-10H,6,11-12H2,1-2H3,(H,19,20)
• InChIKey: YMVWGSQGCWCDGW-UHFFFAOYSA-N
• SMILES: CN(C)CCCNC1=C2C(=NC3=CC=CC=C31)C=CC=C2[N+](=O)[O-]

Nitracrine(CAT: I013284) is a synthetic acridine derivative with potent antitumor activity, primarily used in cancer research. Known for its ability to intercalate into DNA, Nitracrine disrupts the DNA replication process, leading to the inhibition of cancer cell growth and proliferation. This mechanism of action makes it particularly effective against rapidly dividing cells. Nitracrine has shown promise in preclinical studies for treating various types of cancer, including solid tumors. Its chemical structure, featuring a nitro group attached to the acridine core, contributes to its cytotoxic effects. While it demonstrates significant potential, further research is needed to optimize its therapeutic application and reduce toxicity.