For research use only. Not for therapeutic Use.
Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of aldehyde dehydrogenase (ALDH), an enzyme involved in the metabolism of alcohol.
| Catalog Number | R063199 |
| CAS Number | 21721-92-6 |
| Synonyms | 2-methyl-4-nitro-1-(4-nitrophenyl)imidazole |
| Molecular Formula | C10H8N4O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H8N4O4/c1-7-11-10(14(17)18)6-12(7)8-2-4-9(5-3-8)13(15)16/h2-6H,1H3 |
| InChIKey | NMTBSNPBIGRZBL-UHFFFAOYSA-N |
| SMILES | CC1=NC(=CN1C2=CC=C(C=C2)[N+](=O)[O-])[N+](=O)[O-] |
| Reference | [1]. Koda LY, Madamba SG, Bloom FE. Hypotensive response of ethanol in rats pretreated with disulfiram or nitrefazole. Life Sci. 1984;35(16):1659-1665. [2]. Zorzano A, Herrera E. Differences in the kinetic properties and sensitivity to inhibitors of human placental, erythrocyte, and major hepatic aldehyde dehydrogenase isoenzymes. Biochem Pharmacol. 1990;39(5):873-878. |
