Nitrendipine

• CAT Number: A000325
• CAS Number: 39562-70-4
• Molecular Formula: C18H20N2O6
• Molecular Weight: 360.4
• Purity: ≥95%
• Synonyms: 39562-70-4; Bayotensin; Baypress; Nidrel; Nitrendipinum
• Target: Calcium Channel
• Solubility: >13.7mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3
• InChIKey: PVHUJELLJLJGLN-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C

Nitrendipine is a dihydropyridine calcium channel blocker. It is used in the treatment of primary (essential) hypertension to decrease blood pressure and can reduce the cardiotoxicity of cocaine.

Reference

1: Ahad A, Shakeel F, Raish M, Al-Jenoobi FI, Al-Mohizea AM. Solubility and
Thermodynamic Analysis of Antihypertensive Agent Nitrendipine in Different Pure
Solvents at the Temperature Range of 298.15 to 318.15°K. AAPS PharmSciTech. 2017
Mar 20. doi: 10.1208/s12249-017-0759-4. [Epub ahead of print] PubMed PMID:
28321695.

2: Wang Z, Chen Z, Wang X, Hao G, Ma L, Zhao X, Li Y, Zhang L, Zhu M.
Cost-effectiveness of nitrendipine and hydrochlorothiazide or metoprolol to treat
hypertension in rural community health centers in China. J Hypertens. 2017
Apr;35(4):886-892. doi: 10.1097/HJH.0000000000001209. PubMed PMID: 27977472;
PubMed Central PMCID: PMC5338889.

3: Kumar Gaur P, Mishra S, Purohit S. Nanovesicles of nitrendipine with lipid
complex for transdermal delivery: pharmacokinetic and pharmacodynamic studies.
Artif Cells Nanomed Biotechnol. 2016 Nov;44(7):1684-93. doi:
10.3109/21691401.2015.1080170. Epub 2015 Sep 16. PubMed PMID: 26375758.

4: Voruganti S, Yamsani SK, Yamsani MR. Effect of silibinin on the
pharmacokinetics of nitrendipine in rabbits. Eur J Drug Metab Pharmacokinet. 2014
Dec;39(4):277-81. doi: 10.1007/s13318-013-0156-7. Epub 2013 Oct 5. PubMed PMID:
24092617.

5: Mitręga KA, Varghese B, Porc M, Krzemiński TF. Anti-arrhythmic and hemodynamic
effects of oxy nifedipine, oxy nimodipine, oxy nitrendipine and oxy nisoldipine.
Pharmacol Res. 2012 Oct;66(4):300-8. doi: 10.1016/j.phrs.2012.06.008. Epub 2012
Jun 27. PubMed PMID: 22750214.

6: Quan P, Shi K, Piao H, Piao H, Liang N, Xia D, Cui F. A novel surface modified
nitrendipine nanocrystals with enhancement of bioavailability and stability. Int
J Pharm. 2012 Jul 1;430(1-2):366-71. doi: 10.1016/j.ijpharm.2012.04.025. Epub
2012 Apr 13. PubMed PMID: 22531846.

7: Xia D, Wu JX, Cui F, Qu H, Rades T, Rantanen J, Yang M. Solvent-mediated
amorphous-to-crystalline transformation of nitrendipine in amorphous particle
suspensions containing polymers. Eur J Pharm Sci. 2012 Aug 15;46(5):446-54. doi:
10.1016/j.ejps.2012.03.008. Epub 2012 Mar 29. PubMed PMID: 22484330.

8: Liu Y, Wang Z, Sun J, Wang Y, He Z. Ultra-performance liquid
chromatography-tandem mass spectrometry method for the determination of
nitrendipine in dog plasma and its application to a pharmacokinetic study of a
solid self-emulsifying pellet formulation. Arzneimittelforschung.
2011;61(12):674-80. doi: 10.1055/s-0031-1300586. PubMed PMID: 22282953.

9: Voruganti S, Yamsani SK, Ravula SK, Gannu R, Yamsani MR. Effect of pomegranate
juice on intestinal transport and pharmacokinetics of nitrendipine in rats.
Phytother Res. 2012 Aug;26(8):1240-5. doi: 10.1002/ptr.3704. Epub 2012 Jan 25.
PubMed PMID: 22275232.

10: Voruganti S, Rapolu K, Tota S, Yamsani SK, Yamsani MR. Effect of pomegranate
juice on the pharmacokinetics of nitrendipine in rabbits. Eur J Drug Metab
Pharmacokinet. 2012 Jun;37(2):77-81. doi: 10.1007/s13318-011-0075-4. Epub 2011
Nov 22. PubMed PMID: 22101410.