For research use only. Not for therapeutic Use.
Nitrendipine-d5 (CAS: 2469554-26-3), a premium pharmaceutical research compound designed for advanced cardiovascular and antihypertensive studies. As a deuterated analog of Nitrendipine, it offers enhanced stability and improved pharmacokinetic properties. Nitrendipine-d5 is ideal for use in pharmacological and biochemical research, providing precise and reliable data for your studies. This high-purity compound ensures consistent results, aiding in the development of novel therapies for hypertension and heart disease. Trusted by leading laboratories, Nitrendipine-d5 is your go-to solution for cutting-edge cardiovascular research. Unlock new possibilities in blood pressure and heart disease treatment with Nitrendipine-d5, where innovation meets reliability.
| Catalog Number | S000157 |
| CAS Number | 2469554-26-3 |
| Molecular Formula | C18H15D5N2O6 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| IUPAC Name | 3-O-methyl 5-O-(1,1,2,2,2-pentadeuterioethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
| InChI | InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3/i1D3,5D2 |
| InChIKey | PVHUJELLJLJGLN-RPIBLTHZSA-N |
| SMILES | [2H]C([2H])([2H])C([2H])([2H])OC(=O)C1=C(NC(=C(C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC)C)C |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Bellemann, P., et al., [3H]-Nitrendipine, a potent calcium antagonist, binds with high affinity to cardiac membranes. Arzneimittelforschung, 1981. 31(12): p. 2064-7. [3]. S Kazda, et al. Diuretic effect of nitrendipine contributes to its antihypertensive efficacy: a review. J Cardiovasc Pharmacol. 1988;12 Suppl 4:S1-5. [4]. M Bursztyn, et al. Nitrendipine improves glucose tolerance and deoxyglucose uptake in hypertensive rats. Hypertension. 1994 Jun;23(6 Pt 2):1051-3. [5]. He-Hui Xie, et al. Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats. J Hypertens. 2005 Jan;23(1):193-201. |
