For research use only. Not for therapeutic Use.
Nitrocaphane, in combination with 5-FU (fluorouracil), chemotherapy is considered as a protocol of choice in the treatment of malignant trophoblastic tumor.
| Catalog Number | I008305 |
| CAS Number | 54940-95-3 |
| Synonyms | AT-1258; AT1258; AT 1258; Nitrocaphane;(S)-2-amino-3-(2-((bis(2-chloroethyl)amino)methyl)-5-nitrophenyl)propanoic acid |
| Molecular Formula | C14H19Cl2N3O4 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | -20°C |
| IUPAC Name | (2S)-2-amino-3-[2-[bis(2-chloroethyl)aminomethyl]-5-nitrophenyl]propanoic acid |
| InChI | InChI=1S/C14H19Cl2N3O4/c15-3-5-18(6-4-16)9-10-1-2-12(19(22)23)7-11(10)8-13(17)14(20)21/h1-2,7,13H,3-6,8-9,17H2,(H,20,21)/t13-/m0/s1 |
| InChIKey | VEBTZMUIBMIPCD-ZDUSSCGKSA-N |
| SMILES | C1=CC(=C(C=C1[N+](=O)[O-])CC(C(=O)O)N)CN(CCCl)CCCl |
| Reference | </br>1:[Combination chemotherapy of 5-fluorouracil and nitrocaphane for the treatment of malignant trophoblastic tumor]. Ju L, Wang Y, Qu D.Zhonghua Fu Chan Ke Za Zhi. 1996 Apr;31(4):212-5. Chinese. PMID: 8758775 </br>2:Enhancement of nitrocaphane cytotoxicity by hyperthermia in vitro. Li LG, Shen GL, Zhang H, Li DJ.Int J Hyperthermia. 1989 Jul-Aug;5(4):525-33. PMID: 2746055 </br>3:[Thermotolerant kinetics of HEp-2 cells and effect of thermotolerance on cytotoxicity of nitrocaphane]. Shen GL.Zhonghua Zhong Liu Za Zhi. 1989 Mar;11(2):89-91. Chinese. PMID: 2806049 </br>4:[Cytotoxic effect of hyperthermia and nitrocaphane on malignant HEp-2 cells]. Li LG.Zhonghua Zhong Liu Za Zhi. 1989 Jan;11(1):31-3. Chinese. PMID: 2776644 </br>5:[Combined treatment of malignant trophoblastic tumor with 5-fluorouracil and nitrocaphane]. Wang YE.Zhonghua Yi Xue Za Zhi. 1988 Dec;68(12):696-8. Chinese. No abstract available. PMID: 2854752 </br>6:[Antitumor effects of different combinations of oridonin, bleomycin A5 and nitrocaphane]. Zhang TM, Shou MG, Wang MY.Zhongguo Yao Li Xue Bao. 1986 Sep;7(5):457-60. Chinese. No abstract available. PMID: 2438898 Free Article</br>7:[Antitumor activity of nitrocaphane (AT-1258)]. [No authors listed]Zhonghua Yi Xue Za Zhi. 1974;(11):693-6, 193. Chinese. No abstract available. PMID: 4215631 |
