Nivimedone free base

• CAT Number: I033367
• CAS Number: 49561-92-4
• Molecular Formula: C11H9NO4
• Molecular Weight: 219.19
• Purity: 98%
• Synonyms: Nivimedone Free Base; Nivimedona; Nivimedonum
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 5,6-dimethyl-2-nitroindene-1,3-dione
• InChI: InChI=1S/C11H9NO4/c1-5-3-7-8(4-6(5)2)11(14)9(10(7)13)12(15)16/h3-4,9H,1-2H3
• InChIKey: KMQFWCXRCDQFFQ-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C=C1C)C(=O)C(C2=O)[N+](=O)[O-]

Nivimedone free base（Cat No.:I033367）is a compound studied for its potential neuroprotective properties, particularly in the treatment of neurological disorders. It is a derivative of the neurotransmitter precursor, L-dopa, and is thought to act by modulating dopaminergic activity, which is crucial in conditions like Parkinson’s disease. Nivimedone may help reduce oxidative stress and protect dopaminergic neurons from degeneration. Preclinical studies suggest it could improve motor function and delay disease progression in neurodegenerative diseases. However, further clinical research is needed to establish its safety, efficacy, and potential therapeutic applications in neurology.

Reference

1: Lumb EM, McHardy GJ, Kay AB. The orally administered anti-allergic agent, sodium nivimedone (BRL 10833); efficacy in bronchial asthma and effects on IgE, complement and eosinophils. Br J Clin Pharmacol. 1979 Jul;8(1):65-74. doi: 10.1111/j.1365-2125.1979.tb05911.x. PMID: 121884; PMCID: PMC1429720.
2: Spicer BA, Ross JW, Sharpe TJ, Smith H. Peritoneal anaphylaxis in the rat after sensitization with mouse antiserum. Int Arch Allergy Appl Immunol. 1978;56(6):493-9. doi: 10.1159/000232064. PMID: 415988.
3: Meadow SR, Sarsfield JK. Steroid-responsive and nephrotic syndrome and allergy: clinical studies. Arch Dis Child. 1981 Jul;56(7):509-16. doi: 10.1136/adc.56.7.509. PMID: 6791592; PMCID: PMC1627348.
4: Ross JW, Smith H, Spicer BA. Increased vascular permeability during passive peritoneal anaphylaxis in the rat. The effects of disodium cromoglycate and a nitroindanedione. Int Arch Allergy Appl Immunol. 1976;51(2):226-37. doi: 10.1159/000231595. PMID: 58838.
5: Sharpe TJ, Smith H. Effects of drugs on the acute inflammation following intraperitoneal injection of antigen into actively sensitised rats. Int Arch Allergy Appl Immunol. 1979;60(2):216-21. doi: 10.1159/000232344. PMID: 89095.
6: González R, Arruzazabala ML, Sarracent J. Effects of antiallergic drugs on cyclic nucleotides in guinea pig ileum and trachea. Allergol Immunopathol (Madr). 1987 Nov-Dec;15(6):361-3. PMID: 2833089.
7: Sharpe TJ, Ross JW, Spicer BA. The effect of sodium 5,6-dimethyl-2-nitroindanedione on anaphylactic reactions in vitro. Agents Actions. 1978 Apr;8(3):199-202. doi: 10.1007/BF01966603. PMID: 78665.
8: Browne JT, Smyth WF. Polarographic behaviour and analysis of 2-nitro-5,6-dimethylindane-1,3-dione in raw materials and pharmaceutical formulations. Analyst. 1980 Jan;105(1246):25-9. doi: 10.1039/an9800500025. PMID: 7386887.
9: Pauwels R, Lamont H, Van der Straeten M. The inhibition of allergen induced bronchospasm in man by oral BRL 10833. Clin Allergy. 1976 Sep;6(5):471-8. doi: 10.1111/j.1365-2222.1976.tb01931.x. PMID: 824069.
10: Arruzazabala ML, Casacó A, González R, de la Vega AR. Efecto de varias drogas profilácticas antiasmáticas sobre la broncoconstricción inducida por keroseno en conejos [Effect of several antiasthmatic prophylactic drugs on bronchoconstriction induced by kerosene in rabbits]. Allergol Immunopathol (Madr). 1983 Nov-Dec;11(6):421-4. Spanish. PMID: 6422727.