Nizatidine

• CAT Number: A000709
• CAS Number: 76963-41-2
• Molecular Formula: C12H21N5O2S2
• Molecular Weight: 331.50
• Purity: ≥95%
• Synonyms: 76963-41-2; Axid; Acinon; Zanizal; Nizax
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• IUPAC Name: (E)-1-N'-[2-[[2-[(dimethylamino)methyl]-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine
• InChI: InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+
• InChIKey: SGXXNSQHWDMGGP-IZZDOVSWSA-N
• SMILES: CN/C(=C\[N+](=O)[O-])/NCCSCC1=CSC(=N1)CN(C)C

Nizatidine（Cat No.:A000709）is a potent histamine H2 receptor antagonist used primarily to treat gastrointestinal conditions such as ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. By blocking H2 receptors in the stomach lining, it effectively reduces the production of gastric acid, helping to alleviate symptoms associated with acid reflux and promoting the healing of ulcers. Nizatidine is well-known for its rapid action and relatively favorable safety profile, making it a valuable therapeutic option in managing acid-related disorders in both clinical and research settings.

Reference

1: Sanad MH, Saleh GM, Marzook FA. Radioiodination and biological evaluation of
nizatidine as a new highly selective radiotracer for peptic ulcer disorder
detection. J Labelled Comp Radiopharm. 2017 Nov;60(13):600-607. doi:
10.1002/jlcr.3541. Epub 2017 Oct 6. PubMed PMID: 28833386.

2: Sailaja U, Shahin Thayyil M, Krishna Kumar NS, Govindaraj G, Ngai KL.
Molecular mobility in the supercooled and glassy states of nizatidine and
perphenazine. Eur J Pharm Sci. 2017 Mar 1;99:147-151. doi:
10.1016/j.ejps.2016.11.024. Epub 2016 Dec 1. PubMed PMID: 27916696.

3: Viciosa MT, Moura Ramos JJ, Diogo HP. The Slow Relaxation Dynamics in the
Amorphous Pharmaceutical Drugs Cimetidine, Nizatidine, and Famotidine. J Pharm
Sci. 2016 Dec;105(12):3573-3584. doi: 10.1016/j.xphs.2016.08.019. Epub 2016 Oct
20. PubMed PMID: 27773524.

4: Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM. The
Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and
Pharmacodynamics of Metformin in Healthy Volunteers. Clin Pharmacokinet. 2016
Apr;55(4):495-506. doi: 10.1007/s40262-015-0332-9. PubMed PMID: 26507723; PubMed
Central PMCID: PMC4792735.

5: Shang DW, Wang ZZ, Ni XJ, Zhang M, Hu JQ, Qiu C, Wen YG. Development and
validation of a sensitive LC-MS/MS assay for the quantification of nizatidine in
human plasma and urine and its application to pharmacokinetic study. J Chromatogr
B Analyt Technol Biomed Life Sci. 2015 Aug 15;998-999:80-7. doi:
10.1016/j.jchromb.2015.06.026. Epub 2015 Jul 3. PubMed PMID: 26197435.

6: Sakakibara R, Doi H, Sato M, Hirai S, Masaka T, Kishi M, Tsuyusaki Y, Tateno
A, Tateno F, Aiba Y, Ogata T, Suzuki Y. Nizatidine ameliorates slow transit
constipation in Parkinson/’s disease. J Am Geriatr Soc. 2015 Feb;63(2):399-401.
doi: 10.1111/jgs.13279. PubMed PMID: 25688620.

7: Kiszkiel I, Starczewska B, Leśniewska B, Późniak P. Extraction of ranitidine
and nizatidine with using imidazolium ionic liquids prior spectrophotometric and
chromatographic detection. J Pharm Biomed Anal. 2015 Mar 15;106:85-91. doi:
10.1016/j.jpba.2014.11.025. Epub 2014 Nov 20. PubMed PMID: 25498149.

8: Jain A, Pandey V, Ganeshpurkar A, Dubey N, Bansal D. Formulation and
characterization of floating microballoons of nizatidine for effective treatment
of gastric ulcers in murine model. Drug Deliv. 2015 May;22(3):306-11. doi:
10.3109/10717544.2014.891273. Epub 2014 Mar 7. PubMed PMID: 24601855.

9: Doi H, Sakakibara R, Sato M, Hirai S, Masaka T, Kishi M, Tsuyusaki Y, Tateno
A, Tateno F, Takahashi O, Ogata T. Nizatidine ameliorates gastroparesis in
Parkinson/’s disease: a pilot study. Mov Disord. 2014 Apr;29(4):562-6. doi:
10.1002/mds.25777. Epub 2013 Dec 27. PubMed PMID: 24375669.

10: Wang S, Wu B, Xue J, Wang M, Chen R, Wang B. Nizatidine, a small molecular
compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice
from lethal viral challenge. Hum Vaccin Immunother. 2014;10(2):461-8. doi:
10.4161/hv.27165. Epub 2013 Nov 19. PubMed PMID: 24253609; PubMed Central PMCID:
PMC4185914.