NJH-2-030

• CAT Number: I043916
• CAS Number: 2709040-02-6
• Molecular Formula: C19H20ClN3O3
• Molecular Weight: 373.83
• Purity: ≥95%
• Synonyms: 2-chloro-N-(2-cyanoethyl)-N-(4-hex-5-ynoyl-2,3-dihydro-1,4-benzoxazin-7-yl)acetamide
• InChI: InChI=1S/C19H20ClN3O3/c1-2-3-4-6-18(24)23-11-12-26-17-13-15(7-8-16(17)23)22(10-5-9-21)19(25)14-20/h1,7-8,13H,3-6,10-12,14H2
• InChIKey: ICKVAKKMZDTGGB-UHFFFAOYSA-N
• SMILES: C#CCCCC(=O)N1CCOC2=C1C=CC(=C2)N(CCC#N)C(=O)CCl

NJH-2-030 can be used as a covalent recruiter for FEM1B in targeted protein degradation applications.

Reference

[1]. Henning NJ, et al. Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications. J Am Chem Soc. 2022 Jan 19;144(2):701-708.
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