NK-252

• CAT Number: I001580
• CAS Number: 1414963-82-8
• Molecular Formula: C13H11N5O3
• Molecular Weight: 285.26
• Purity: ≥95%
• Synonyms: N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-N/’-(2-pyridinylmethyl)-urea
• Target: Keap1-Nrf2
• Solubility: DMSO: ≥ 29 mg/mL
• Storage: Store at 2-8°C
• IUPAC Name: 1-[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]-3-(pyridin-2-ylmethyl)urea
• InChI: InChI=1S/C13H11N5O3/c19-12(15-8-9-4-1-2-6-14-9)16-13-18-17-11(21-13)10-5-3-7-20-10/h1-7H,8H2,(H2,15,16,18,19)
• InChIKey: FNSCFQXZZNCDAI-UHFFFAOYSA-N
• SMILES: C1=CC=NC(=C1)CNC(=O)NC2=NN=C(O2)C3=CC=CO3

NK-252（Cat No.:I001580） is a Nrf2 activator that exhibits greater Nrf2 activation potential than OPZ. NK-252 interacts with the Nrf2 binding site of Keap1. NK-252 reduces the expression of factor-β1 (TGF-β1), collagen α1(I), and tissue inhibitor of metalloproteinase-1 (TIMP-1). Administration of NK-252 almost completely inhibited the infiltration of inflammatory cells in the peribiliary area.