NL-1

• CAT Number: I017526
• CAS Number: 188532-26-5
• Molecular Formula: C₁₈H₂₅NO₃S
• Molecular Weight: 335.46
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 5-[(3,5-ditert-butyl-4-hydroxyphenyl)methyl]-1,3-thiazolidine-2,4-dione
• InChI: InChI=1S/C18H25NO3S/c1-17(2,3)11-7-10(8-12(14(11)20)18(4,5)6)9-13-15(21)19-16(22)23-13/h7-8,13,20H,9H2,1-6H3,(H,19,21,22)
• InChIKey: QDYYSPGKYXWGSL-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CC2C(=O)NC(=O)S2

NL-1（Cat No.:I017526）is a selective and potent inhibitor of the TRPM2 (transient receptor potential melastatin 2) ion channel, which is involved in calcium influx and linked to oxidative stress and inflammatory processes in cells. By blocking TRPM2, NL-1 helps prevent calcium overload in cells, making it a useful research tool for studying neurodegenerative diseases, ischemic injuries, and inflammatory disorders where TRPM2 activity exacerbates cellular damage. Its specificity allows for precise investigation into TRPM2’s role in disease mechanisms, providing insights for potential therapeutic interventions targeting TRPM2-mediated pathways.

Reference

[1]. Geldenhuys WJ, et al. The MitoNEET Ligand NL-1 Mediates Antileukemic Activity in Drug-Resistant B-Cell Acute Lymphoblastic Leukemia. J Pharmacol Exp Ther. 2019 Jul;370(1):25-34.