NLRP3 agonist 1

• CAT Number: I040558
• CAS Number: 2454019-69-1
• Molecular Formula: C15H16N6
• Molecular Weight: 280.33
• Purity: ≥95%
• Synonyms: 4-N-(1-methylcyclopropyl)-7-(1H-pyrazol-5-yl)quinazoline-2,4-diamine
• InChI: InChI=1S/C15H16N6/c1-15(5-6-15)20-13-10-3-2-9(11-4-7-17-21-11)8-12(10)18-14(16)19-13/h2-4,7-8H,5-6H2,1H3,(H,17,21)(H3,16,18,19,20)
• InChIKey: KNPJIDCHCYGPIK-UHFFFAOYSA-N
• SMILES: CC1(CC1)NC2=NC(=NC3=C2C=CC(=C3)C4=CC=NN4)N

NLRP3 agonist 1 (compound 23) is a potent and orally active NLRP3 agonist. NLRP3 agonist 1 can activate the enzyme Caspase-1 to cleave pro-IL-1β and pro-IL-18 proinflammatory cytokines into their mature forms[1].

Reference

[1]. O’ Donovan DH, et, al. Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice. Bioorg Med Chem Lett. 2023 Oct 12:96:129518.
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