NLRP3/AIM2-IN-2

• CAT Number: I045194
• CAS Number: 791840-86-3
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.28
• Purity: ≥95%
• Synonyms: N-(3-hydroxyphenyl)-2-(4-methoxyphenyl)acetamide
• InChI: InChI=1S/C15H15NO3/c1-19-14-7-5-11(6-8-14)9-15(18)16-12-3-2-4-13(17)10-12/h2-8,10,17H,9H2,1H3,(H,16,18)
• InChIKey: OTXSEOHBMQFDBM-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)CC(=O)NC2=CC(=CC=C2)O

NLRP3/aim2-in-2 (compound 8) is a new potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent cell death. Its < b > IC < sub > 50 < / sub > < / b > value is 0.2392 ± 0.0233 μ M。

Reference

[1]. Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Feb 11;232:114194.
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