For research use only. Not for therapeutic Use.
NLRP3-IN-18 (Cat No.: I041150) is a potent and selective small-molecule inhibitor of the NLRP3 inflammasome, a key regulator of innate immune responses involved in the activation of caspase-1 and release of IL-1β and IL-18. By blocking NLRP3 activation, NLRP3-IN-18 suppresses inflammation without affecting other inflammasome pathways such as AIM2 or NLRC4. It is a valuable tool for studying autoinflammatory diseases, neuroinflammation, and metabolic disorders where NLRP3 plays a pathogenic role. For research use only in immunology and inflammation-related investigations.
| CAS Number | 2769040-06-2 |
| Synonyms | 4-(4-chlorophenyl)-N-[[(2S)-oxolan-2-yl]methyl]phthalazin-1-amine |
| Molecular Formula | C19H18ClN3O |
| Purity | ≥95% |
| InChI | InChI=1S/C19H18ClN3O/c20-14-9-7-13(8-10-14)18-16-5-1-2-6-17(16)19(23-22-18)21-12-15-4-3-11-24-15/h1-2,5-10,15H,3-4,11-12H2,(H,21,23)/t15-/m0/s1 |
| InChIKey | FVFXAPATLSJYGX-HNNXBMFYSA-N |
| SMILES | C1CC(OC1)CNC2=NN=C(C3=CC=CC=C32)C4=CC=C(C=C4)Cl |
| Reference | [1]. Stéphane DORICH, et al. Pyridazine compounds for inhibiting nlrp3. WO2022216971A1. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
