NM107

For research use only, not for therapeutic use.

  • CAT Number: I002595
  • CAS Number: 20724-73-6
  • Molecular Formula: C10H15N3O5
  • Molecular Weight: 257.24
  • Purity: 95%
Inquiry Now

NM107 (CAT: I002595), also known as 2′-C-Methylcytidine, is a compound that has shown inhibitory activity against HCV (Hepatitis C Virus) and other related viruses. It acts as an inhibitor of HCV RNA replication, with an IC50 of 7.0 μM in vitro. NM107 has demonstrated potent and selective inhibitory activity against flavi- and pestivirus replication in cell culture, including HCV 1b replicon cells, with an IC50 of 1.13 μM. It has also shown inhibitory activity against bovine viral diarrhea virus (BVDV) replication, with an EC50 of 0.67 nM, and has the ability to eliminate persistent BVDV infection at non-toxic concentrations. These properties make NM107 a promising candidate for further investigation as a therapeutic agent for HCV infection and other viral infections.


Catalog Number I002595
CAS Number 20724-73-6
Synonyms

2′-C-Methylcytidine;NM-107

Molecular Formula C10H15N3O5
Purity 95%
Target HCV RNA replication
Solubility 10 mM in DMSO
Appearance powder
Storage 3 years -20C powder
IC50 7.0 μM
IUPAC Name 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one
InChI InChI=1S/C10H15N3O5/c1-10(17)7(15)5(4-14)18-8(10)13-3-2-6(11)12-9(13)16/h2-3,5,7-8,14-15,17H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,10-/m1/s1
InChIKey PPUDLEUZKVJXSZ-VPCXQMTMSA-N
SMILES CC1(C(C(OC1N2C=CC(=NC2=O)N)CO)O)O
Reference

<p style=”/line-height:25px/”>
<br />
[1]. McCown MF, et al. The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleosidepolymerase or protease inhibitors. Antimicrob Agents Chemother. 2008 May;52(5):1604-1612.</p>

Request a Quote