NMDA

• CAT Number: I004411
• CAS Number: 6384-92-5
• Molecular Formula: C5H9NO4
• Molecular Weight: 147.10
• Purity: ≥95%
• Synonyms: (2R)-2-(methylamino)butanedioic acid
• Target: Neuronal Signaling
• Solubility: H2O: 30 mg/mL, DMSO: 5 mg/mL
• Storage: 3 years -20C powder
• InChI: InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
• InChIKey: HOKKHZGPKSLGJE-GSVOUGTGSA-N
• SMILES: CN[C@H](CC(=O)O)C(=O)O

N-Methyl-D-Aspartate (NMDA)（Cat No.:I004411）is a synthetic amino acid that functions as a potent agonist at the NMDA receptor, a subtype of glutamate receptor in the brain. The NMDA receptor is involved in synaptic plasticity, learning, and memory processes, as well as in various neurophysiological and neurodegenerative conditions. Activation of this receptor allows calcium ions to flow into the cell, which plays a crucial role in excitatory neurotransmission. Dysregulation of NMDA receptor activity is implicated in disorders like schizophrenia, Alzheimer’s disease, and epilepsy, making NMDA receptor modulators a target for therapeutic research.

Reference

[1]. Dingledine R, et al. The glutamate receptor ion channels. Pharmacol Rev. 1999 Mar;51(1):7-61.
[2]. Liu Y, et al. Recent development in NMDA receptors. Chin Med J (Engl). 2000 Oct;113(10):948-56.
[3]. Cull-Candy S, et al. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol. 2001 Jun;11(3):327-35.