For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>NMDA(N-Methyl-D-aspartic acid) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.<br>IC50 value:<br>Target: NMDA receptor<br>NMDA is a water-soluble synthetic substance that is not normally found in biological tissue. It was first synthesized in the 1960s. NMDA is an excitotoxin (it kills nerve cells by over-exciting them); this trait has applications in behavioral neuroscience research. The body of work utilizing this technique falls under the term /lesion studies/. Researchers apply NMDA to specific regions of an (animal) subject/’s brain or spinal cord and subsequently test for the behavior of interest, such as operant behavior. If the behavior is compromised, it suggests the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behavior. The mechanism of stimulating NMDA receptor is a specific agonist-binding to its NR2 subunits, and then a non-specific cation channel is opened, which can allow the passage of Ca2+ and Na+ into the cell and K+ out of the cell. The excitatory postsynaptic potential (EPSP) produced by activation of an NMDA receptor also increases the concentration of Ca2+ in the cell. The Ca2+ can in turn function as a second messenger in various signaling pathways. [1][2][3]</p>
| Catalog Number | I004411 |
| CAS Number | 6384-92-5 |
| Synonyms | (2R)-2-(methylamino)butanedioic acid |
| Molecular Formula | C5H9NO4 |
| Purity | ≥95% |
| Target | GluR |
| Solubility | H2O: 30 mg/mL, DMSO: 5 mg/mL |
| Storage | 3 years -20C powder |
| InChIKey | HOKKHZGPKSLGJE-GSVOUGTGSA-N |
| Reference | <p style=/line-height:25px/> |
