NMDAR antagonist 1

• CAT Number: I009738
• CAS Number: 2220162-06-9
• Molecular Formula: C₂₀H₂₀BrN₃O₂
• Molecular Weight: 414.3
• Purity: ≥95%

NMDAR antagonist 1 is a potent and orally bioavailable NR2B-selective NMDAR antagonist[1].NMDAR antagonist 1 (Compound 5q) exhibits excellent neuroprotective activity[1].
NMDAR antagonist 1 can attenuate Ca2+ influx induced by NMDA[1].
NMDAR antagonist 1 can suppress the NR2B up-regulation and increase p-ERK1/2 expression[1].
NMDAR antagonist 1 inhibits SH-SY5Y cells with cell viabilities of 75.8%, 80.0%, 84.4%, and 78.6% at 0.1 µM 1 µM 10 µM 100 µM, respectively[1].

Reference

[1]. Zhang L, et al. Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents. Eur J Med Chem. 2018 May 10;151:27-38.