For research use only. Not for therapeutic Use.
C19 is an NMDAR/TRPM4 (N/T) interaction interface inhibitor with an IC50 value of 1.1 μM for NMDA-induced cell death in hippocampal neurons. This inhibitor strongly reduced NMDA-triggered toxicity and mitochondrial dysfunction, abolished cyclic adenosine monophosphate-responsive element-binding protein (CREB) shutoff, boosted gene induction, and reduced neuronal loss in mouse models of stroke and retinal degeneration. Potent neuroprotectant.
NMDAR-TRPM4 blocker C8 is available as Axon 3348.
KEYWORDS: C19 | supplier | NMDAR/TRPM4 inhibitor | FMP-A-02 | Aliudanexin | CAS [2241128-93-6] | [1456994-27-6] | [2031688-95-4] | Glutamate | NMDA | Inhibitor | Ion Channels | Stroke | Traumatic brain injury | Alzheimer’s disease | Huntington’s disease | Amyotrophic lateral sclerosis | Retinal degeneration | Neuroprotectant
| Catalog Number | I047667 |
| CAS Number | 2241128-93-6 |
| Molecular Formula | C13H16Cl3N3O.2HCl |
| Purity | ≥95% |
| IUPAC Name | 2-[3-(aminomethyl)pyrrolidin-1-yl]-N-(2,4,5-trichlorophenyl)acetamide;dihydrochloride |
| InChI | InChI=1S/C13H16Cl3N3O.2ClH/c14-9-3-11(16)12(4-10(9)15)18-13(20)7-19-2-1-8(5-17)6-19;;/h3-4,8H,1-2,5-7,17H2,(H,18,20);2*1H |
| SMILES | C1CN(CC1CN)CC(=O)NC2=CC(=C(C=C2Cl)Cl)Cl.Cl.Cl |
| Reference | J Yan et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370(6513). |
