For research use only. Not for therapeutic Use.
S29434（Cat No.:I012361）, also known as NMDPEF, is a potent and selective inhibitor of quinone reductase 2 (QR2). It exhibits high affinity for human QR2 with IC50 values ranging from 5 to 16nM in different tissues, displaying higher selectivity towards QR2 compared to QR1. By inhibiting QR2, S29434 inhibits the production of reactive oxygen species (ROS) mediated by QR2 and can induce autophagy. Its membrane permeability allows for efficient cellular uptake, making it a valuable tool in studying QR2-related processes and potential therapeutic applications targeting ROS and autophagy.
| Catalog Number | I012361 |
| CAS Number | 874484-20-5 |
| Synonyms | S29434; N-[2-(2-methoxy-6H-dipyrido[2,3-a:3/’,2/’-e]pyrrolizin-11-yl)ethyl]-2-furamide |
| Molecular Formula | C21H18N4O3 |
| Purity | ≥95% |
| Target | Autophagy |
| Storage | 2-8°C |
| IUPAC Name | N-[2-(5-methoxy-1,6,11-triazatetracyclo[7.7.0.02,7.010,15]hexadeca-2(7),3,5,8,10(15),11,13-heptaen-8-yl)ethyl]furan-2-carboxamide |
| InChI | InChI=1S/C21H18N4O3/c1-27-17-7-6-15-19(24-17)14(8-10-23-21(26)16-5-3-11-28-16)20-18-13(12-25(15)20)4-2-9-22-18/h2-7,9,11H,8,10,12H2,1H3,(H,23,26) |
| InChIKey | XJIUMLVQBQKCJA-UHFFFAOYSA-N |
| SMILES | COC1=NC2=C(C=C1)N3CC4=C(C3=C2CCNC(=O)C5=CC=CO5)N=CC=C4 |
