NMT-IN-1

• CAT Number: I041716
• CAS Number: 326879-46-3
• Molecular Formula: C15H14N2OS
• Molecular Weight: 270.35
• Purity: ≥95%
• Synonyms: 2-phenyl-3-(pyridin-2-ylmethyl)-1,3-thiazolidin-4-one
• InChI: InChI=1S/C15H14N2OS/c18-14-11-19-15(12-6-2-1-3-7-12)17(14)10-13-8-4-5-9-16-13/h1-9,15H,10-11H2
• InChIKey: OUFWVMWVSGJVGV-UHFFFAOYSA-N
• SMILES: C1C(=O)N(C(S1)C2=CC=CC=C2)CC3=CC=CC=N3

NMT-IN-1 (compound 9) is a potent N-Myristoyltransferase (NMT) Inhibitor with IC50 values of 31 and 66 μM for TbNMT and hNMT, respectively. NMT-IN-1 can be used in research of african trypanosomiasis[1].

Reference

[1]. Spinks D, et, al. Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode. ChemMedChem. 2015 Nov;10(11):1821-36.
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