For research use only. Not for therapeutic Use.
Epoxyeicosatrienoic acids (EETs), lipid mediators synthesized from arachidonic acid by cytochrome P-<wbr></wbr>450 epoxygenases, are converted by soluble epoxide hydrolase (sEH) to the corresponding dihydroxyeicosatrienoic acids (DHETs). N,N’ Dicyclohexylurea (DCU) is a selective sEH inhibitor with IC<sub>50</sub> values of 160 and 90 nM for recombinant human and mouse sEH, respectively. At 10 µM, DCU blocks the hydrolysis of <em>cis</em>-<wbr></wbr> and trans-<wbr></wbr>EETs by rat red blood cells and porcine coronary endothelial cells as well as completely inhibits 14,(15)-<wbr></wbr>EET-<wbr></wbr>induced PPARα activation.
| Catalog Number | R019986 |
| CAS Number | 2387-23-7 |
| Synonyms | 1,3-Dicyclohexylurea; DCU; Dicyclohexylcarbodiamide; NSC 17013; NSC 30023; |
| Molecular Formula | C13H24N2O |
| Purity | ≥95% |
| Target | Epoxide Hydrolase |
| Storage | -20°C |
| IUPAC Name | 1,3-dicyclohexylurea |
| InChI | InChI=1S/C13H24N2O/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12H,1-10H2,(H2,14,15,16) |
| InChIKey | ADFXKUOMJKEIND-UHFFFAOYSA-N |
| SMILES | C1CCC(CC1)NC(=O)NC2CCCCC2 |
