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Home > Reference Standards> N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamide Hydrochloride
209808-47-9-N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamide Hydrochloride N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamide Hydrochloride

N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamide Hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: R042427
  • CAS Number: 209808-47-9
  • Molecular Formula: C23H29ClN2O
  • Molecular Weight: 384.948
  • Purity: ≥95%
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Related Small Molecules: (R)-4-ISOPROPYL-1,3-OXAZOLIDINE-2-THIONE     2,6-Dichloro-N-(2,6-dimethylphenyl)hexanamide     4-Fluoro-3-methylphenylboronic acid    

AR-M1000390 is a nonpeptidic δ receptor selective agonist.


Catalog Number R042427
CAS Number 209808-47-9
Synonyms

N,N-Diethyl-4-(phenyl-4-piperidinylidenemethyl)benzamide Monohydrochloride

Molecular Formula C23H29ClN2O
Purity ≥95%
Target Neuronal Signaling
Solubility Soluble in DMSO > 10 mM
Storage Store at -20C
IUPAC Name N,N-diethyl-4-[phenyl(piperidin-4-ylidene)methyl]benzamide;hydrochloride
InChI InChI=1S/C23H28N2O.ClH/c1-3-25(4-2)23(26)21-12-10-19(11-13-21)22(18-8-6-5-7-9-18)20-14-16-24-17-15-20;/h5-13,24H,3-4,14-17H2,1-2H3;1H
InChIKey OTXTZCLQEGSAMW-UHFFFAOYSA-N
SMILES CCN(CC)C(=O)C1=CC=C(C=C1)C(=C2CCNCC2)C3=CC=CC=C3.Cl
Reference

</br>1: Nozaki C, Nagase H, Nemoto T, Matifas A, Kieffer BL, Gaveriaux-Ruff C. In vivo properties of KNT-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice. Br J Pharmacol. 2014 Dec;171(23):5376-86. doi: 10.1111/bph.12852. PubMed PMID: 25048778; PubMed Central PMCID: PMC4294046.</br>2: Pradhan AA, Walwyn W, Nozaki C, Filliol D, Erbs E, Matifas A, Evans C, Kieffer BL. Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance. J Neurosci. 2010 Dec 8;30(49):16459-68. doi: 10.1523/JNEUROSCI.3748-10.2010. PubMed PMID: 21147985; PubMed Central PMCID: PMC3086517.</br>3: Pradhan AA, Becker JA, Scherrer G, Tryoen-Toth P, Filliol D, Matifas A, Massotte D, Gavériaux-Ruff C, Kieffer BL. In vivo delta opioid receptor internalization controls behavioral effects of agonists. PLoS One. 2009;4(5):e5425. doi: 10.1371/journal.pone.0005425. PubMed PMID: 19412545; PubMed Central PMCID: PMC2672171.</br>4: Otieno MA, Bavuso N, Milano J, Foster-Brown L, Bui KH, Li Y, Hudzik T, Wescott D, Louden C, Dyroff M, Pognan F. Mechanistic investigation of N,N-diethyl-4-(phenyl-piperidin-4-ylidenemethyl)-benzamide-induced insulin depletion in the rat and RINm5F cells. Toxicol Sci. 2008 Sep;105(1):221-9. doi: 10.1093/toxsci/kfn108. PubMed PMID: 18539914.</br>5: Marie N, Landemore G, Debout C, Jauzac P, Allouche S. Pharmacological characterization of AR-M1000390 at human delta opioid receptors. Life Sci. 2003 Aug 15;73(13):1691-704. PubMed PMID: 12875901.</br>6: Wei ZY, Brown W, Takasaki B, Plobeck N, Delorme D, Zhou F, Yang H, Jones P, Gawell L, Gagnon H, Schmidt R, Yue SY, Walpole C, Payza K, St-Onge S, Labarre M, Godbout C, Jakob A, Butterworth J, Kamassah A, Morin PE, Projean D, Ducharme J, Roberts E. N,N-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues. J Med Chem. 2000 Oct 19;43(21):3895-905. PubMed PMID: 11052794.</br></br>

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