For research use only. Not for therapeutic Use.
N,N-Dimethylacetamide-d9 is the deuterium labeled N,N-Dimethylacetamide[1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent[2].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
| Catalog Number | M088604 |
| CAS Number | 16727-10-9 |
| Synonyms | 2,2,2-trideuterio-N,N-bis(trideuteriomethyl)acetamide |
| Molecular Formula | C4D9NO |
| Purity | ≥95% |
| InChI | InChI=1S/C4H9NO/c1-4(6)5(2)3/h1-3H3/i1D3,2D3,3D3 |
| InChIKey | FXHOOIRPVKKKFG-GQALSZNTSA-N |
| SMILES | CC(=O)N(C)C |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Sundaram S, et al. N,N-dimethylacetamide regulates the proinflammatory response associated with endotoxin and prevents preterm birth. Am J Pathol. 2013 Aug;183(2):422-30. |
