For research use only. Not for therapeutic Use.
N,N’-DME-N-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016091 |
| CAS Number | 2279944-69-1 |
| Synonyms | tert-butyl 3-[2-[2-[methyl-[2-(methylamino)ethyl]amino]ethoxy]ethoxy]propanoate |
| Molecular Formula | C15H32N2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H32N2O4/c1-15(2,3)21-14(18)6-10-19-12-13-20-11-9-17(5)8-7-16-4/h16H,6-13H2,1-5H3 |
| InChIKey | VROYCYWEWWSVEE-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)CCOCCOCCN(C)CCNC |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
