N,N'-DME-N,N'-Bis-PEG2-acid

• CAT Number: I015693
• CAS Number: 2062663-61-8
• Molecular Formula: C₁₈H₃₆N₂O₈
• Molecular Weight: 408.49
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 3-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethyl-methylamino]ethyl-methylamino]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C18H36N2O8/c1-19(7-11-27-15-13-25-9-3-17(21)22)5-6-20(2)8-12-28-16-14-26-10-4-18(23)24/h3-16H2,1-2H3,(H,21,22)(H,23,24)
• InChIKey: LCVJNRDGGKVUKH-UHFFFAOYSA-N
• SMILES: CN(CCN(C)CCOCCOCCC(=O)O)CCOCCOCCC(=O)O

N,N’-DME-N,N’-Bis-PEG2-acid（Cat No.:I015693）is a compound consisting of two polyethylene glycol (PEG) chains, each with two ethylene glycol units (PEG2), linked to an N,N’-dimethyl (DME) functional group and a carboxylic acid group. The PEG2 segments enhance water solubility, stability, and biocompatibility, making this molecule useful in drug delivery and biomedical applications. The carboxylic acid group can be used for conjugation to other biomolecules or drugs, while the DME group provides additional steric protection or solubility enhancement. This compound is often utilized in the design of bioconjugates, targeted therapies, and controlled-release drug formulations.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562