For research use only. Not for therapeutic Use.
NNMTi（Cat No.:I033405）is a class of small molecule inhibitors targeting the enzyme nicotinamide N-methyltransferase (NNMT), which is involved in the metabolism of nicotinamide (a form of vitamin B3) and the regulation of cellular energy balance. NNMT is implicated in various metabolic diseases, including obesity, insulin resistance, and certain cancers. By inhibiting NNMT, NNMTi compounds aim to modulate metabolic pathways, potentially improving conditions like metabolic syndrome and reducing tumor growth. Preclinical studies suggest NNMTi may have therapeutic benefits in managing metabolic disorders and cancer, although further clinical trials are needed to confirm their efficacy and safety.
| Catalog Number | I033405 |
| CAS Number | 42464-96-0 |
| Synonyms | NNMTi |
| Molecular Formula | C10H11IN2 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 1-methylquinolin-1-ium-5-amine;iodide |
| InChI | InChI=1S/C10H10N2.HI/c1-12-7-3-4-8-9(11)5-2-6-10(8)12;/h2-7,11H,1H3;1H |
| InChIKey | JPEZFBFIRRAFNR-UHFFFAOYSA-N |
| SMILES | C[N+]1=CC=CC2=C(C=CC=C21)N.[I-] |
| Reference | Neelakantan et al (2019) Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem. Pharmacol. 163 481 PMID: 30753815 |
