NNMTi

• CAT Number: I033405
• CAS Number: 42464-96-0
• Molecular Formula: C10H11IN2
• Molecular Weight: 286.1165
• Purity: 98%
• Synonyms: NNMTi
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 5-Amino-1-methylquinolinium iodide
• InChI: InChI=1S/C10H10N2.HI/c1-12-7-3-4-8-9(11)5-2-6-10(8)12;/h2-7,11H,1H3;1H
• InChIKey: JPEZFBFIRRAFNR-UHFFFAOYSA-N
• SMILES: C[N+]1=C2C=CC=C(N)C2=CC=C1.[I-]

NNMTi is a nicotinamide N-methyltransferase (NNMT) inhibitor that promotes myoblast differentiation.

Reference

Neelakantan et al (2019) Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem. Pharmacol. 163 481 PMID: 30753815
Neelakantan et al (2017) Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J.Med.Chem. 60 5015 PMID: 28548833