NO-1886

• CAT Number: R065546
• CAS Number: 133208-93-2
• Molecular Formula: C19H20BrN2O4P
• Molecular Weight: 451.257
• Purity: ≥95%
• Synonyms: Ibrolipim;Lipoprotein Lipase Activator;LPL Activator;OPF 009
• Storage: -20°C
• IUPAC Name: N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide
• InChI: InChI=1S/C19H20BrN2O4P/c1-3-25-27(24,26-4-2)13-14-5-7-15(8-6-14)19(23)22-18-10-9-17(20)11-16(18)12-21/h5-11H,3-4,13H2,1-2H3,(H,22,23)
• InChIKey: KPRTURMJVWXURQ-UHFFFAOYSA-N
• SMILES: CCOP(=O)(CC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)Br)C#N)OCC

Lipoprotein lipase (LPL) mediates the hydrolysis of triglycerides in circulating very low density lipoproteins and chylomicrons. NO-1886 is an LPL activator that increases LPL mRNA and LPL activity in adipose tissue, myocardium, and skeletal muscle. This coincides with an elevation in post-heparin plasma LPL activity and LPL mass in rats. NO-1886 decreases plasma triglyceride concentration and increases plasma high-density lipoprotein cholesterol, resulting in inhibited development of atherosclerotic lesions in coronary arteries and aortas of rats and rabbits.

Reference

1.Kim, M.S.,Wang, Y. and Rodrigues, B. Lipoprotein lipase mediated fatty acid delivery and its impact in diabetic cardiomyopathy. Biochimica et Biophysica Acta 1821(5), 800-808 (2011).