NO2-SPDB-sulfo

• CAT Number: I015283
• CAS Number: 663598-89-8
• Molecular Formula: C₁₃H₁₃N₃O₉S₃
• Molecular Weight: 451.45
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: 1-[4-[(5-nitropyridin-2-yl)disulfanyl]butanoyloxy]-2,5-dioxopyrrolidine-3-sulfonic acid
• InChI: 1S/C13H13N3O9S3/c17-11-6-9(28(22,23)24)13(19)15(11)25-12(18)2-1-5-26-27-10-4-3-8(7-14-10)16(20)21/h3-4,7,9H,1-2,5-6H2,(H,22,23,24)
• InChIKey: AJTQYMNCOAZOGJ-UHFFFAOYSA-N
• SMILES: C1C(C(=O)N(C1=O)OC(=O)CCCSSC2=NC=C(C=C2)[N+](=O)[O-])S(=O)(=O)O

NO2-SPDB-sulfo (Cat No.: I015283) is a bioconjugation reagent used in drug delivery and antibody-drug conjugate (ADC) research. It contains a nitro (NO₂) group and an SPDB (N-succinimidyl 4-(2-pyridyldithio)butanoate) linker, which facilitates thiol-based conjugation and controlled drug release. The sulfo group enhances water solubility, making it suitable for biological applications. NO2-SPDB-sulfo is commonly utilized in targeted therapies, enabling precise drug delivery to diseased cells while minimizing systemic toxicity. Its role in ADC development contributes to advancements in cancer treatment and precision medicine.

Reference

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.