Nobiletin

• CAT Number: I003671
• CAS Number: 478-01-3
• Molecular Formula: C21H22O8
• Molecular Weight: 402.40
• Purity: ≥95%
• Synonyms: NSC 76751;NSC 618903
• Target: MMP
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: 3 years -20℃ powder
• IUPAC Name: 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
• InChI: InChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3
• InChIKey: MRIAQLRQZPPODS-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC)OC

Nobiletin（Cat No.:I003671）is a polymethoxyflavonoid derived from citrus peels, recognized for its potent antioxidant, anti-inflammatory, and anti-cancer properties. It promotes cellular health by modulating multiple signaling pathways, including PI3K/Akt, NF-κB, and MAPK, making it valuable in cardiovascular and neurodegenerative disease research. Nobiletin also enhances lipid metabolism, offering potential benefits in managing obesity and metabolic syndrome. Due to its multi-targeted action and natural origin, Nobiletin is widely studied as a therapeutic agent for chronic diseases, providing promising applications in preventive medicine and functional health research.

Reference

[1]. Takito J, et al. Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells. Can J Physiol Pharmacol. 2016 Feb 12:1-6.
[2]. He B, et al. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21.
[3]. Cheng HL, et al. Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget. 2016 Apr 29.