NOD-IN-1

• CAT Number: I001248
• CAS Number: 132819-92-2
• Molecular Formula: C18H17NO4S
• Molecular Weight: 343.4
• Purity: ≥95%
• Target: NOD-like Receptor (NLR)
• Solubility: 10 mM in DMSO
• Storage: 2-8°C
• IUPAC Name: ethyl 1-(4-methylphenyl)sulfonylindole-2-carboxylate
• InChI: InChI=1S/C18H17NO4S/c1-3-23-18(20)17-12-14-6-4-5-7-16(14)19(17)24(21,22)15-10-8-13(2)9-11-15/h4-12H,3H2,1-2H3
• InChIKey: OJMOGUKIYRAILM-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=CC2=CC=CC=C2N1S(=O)(=O)C3=CC=C(C=C3)C

NOD-IN-1, also known as MDK19922, Compound 4, is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptor 1 (NOD1) and NOD2, with corresponding IC50 values of 5.74 μM and 6.45 μM, respectively.

Reference

[1].?Ke?ek Ple?ec K, et al. Identification of indole scaffold-based dual inhibitors of NOD1 and NOD2. Bioorg Med Chem. 2016 Nov 1;24(21):5221-5234.
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