Nolatrexed Dihydrochloride

• CAT Number: R008557
• CAS Number: 152946-68-4
• Molecular Formula: C14H14Cl2N4OS
• Molecular Weight: 357.25
• Purity: ≥95%
• Synonyms: 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride; AG 337; Thymitaq
• Target: Thymidylate Synthase
• Solubility: >17.2mg/mL in DMSO
• Storage: Store at -20°C
• IUPAC Name: 2-amino-6-methyl-5-pyridin-4-ylsulfanyl-1H-quinazolin-4-one;dihydrochloride
• InChI: InChI=1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H
• InChIKey: PJKVJJYMWOCLIJ-UHFFFAOYSA-N
• SMILES: CC1=C(C2=C(C=C1)NC(=NC2=O)N)SC3=CC=NC=C3.Cl.Cl

Nolatrexed Dihydrochloride（Cat No. : R008557） is an antifolate drug that inhibits dihydrofolate reductase (DHFR), an enzyme involved in DNA synthesis and cell replication. By blocking DHFR, Nolatrexed interferes with the production of tetrahydrofolate, essential for nucleotide synthesis, thereby inhibiting cancer cell proliferation. It has shown activity against various cancers, including lung, colorectal, and gastric cancers. Nolatrexed Dihydrochloride is being investigated as a chemotherapy agent, with its ability to target rapidly dividing tumor cells making it a promising option in cancer treatment.