For research use only. Not for therapeutic Use.
Monovalent cation ionophore that displays selectivity for K<sup>+</sup> and NH<sub>4</sub><sup>+</sup> (K<sup>+</sup> = NH<sub>4</sub><sup>+</sup> > Na<sup>+</sup> > Mg<sup>2+</sup> > Li<sup>+</sup> >> Ca<sup>2+</sup> for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.
| Catalog Number | I010567 |
| CAS Number | 6833-84-7 |
| Synonyms | Alternative Name: Ammonium Ionophore I |
| Molecular Formula | C40H64O12 |
| Purity | ≥95% |
| Target | Potassium Channel |
| Solubility | Soluble to 10 mM in ethanol |
| Storage | Desiccate at -20C |
| InChI | InChI=1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36- |
| InChIKey | RMIXHJPMNBXMBU-QIIXEHPYSA-N |
| SMILES | CC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)C)C)C)C |
| Reference | Uber Untersuchungen, welche zur Bestimmung der Konfiguration der Nonactinsaure und der Homononactinsaure ausgefiihrt wurden, werden wir in einer spateren Mitteilung berichten. Dominguez J. et al. Helv. Chim. Acta 1962, 45, 129.<br/><br/>Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Graven S. N. et al. Biochemistry, 1966, 5, 1735.</span></p> |
