For research use only. Not for therapeutic Use.
Nonaethylene glycol is a polyethylene glycol (PEG)-based linker commonly utilized in the synthesis of PROTACs (proteolysis-targeting chimeras). As a flexible and hydrophilic linker, it provides a spacer between the target-binding ligand and the ligand for E3 ubiquitin ligase, facilitating proximity-induced protein degradation. Nonaethylene glycol allows for efficient conjugation and formation of stable linkages in PROTAC design. By incorporating this linker, PROTACs can selectively recruit target proteins for ubiquitination and subsequent degradation, offering a powerful strategy for targeted protein modulation in various biomedical and therapeutic applications.
| Catalog Number | I016667 |
| CAS Number | 3386-18-3 |
| Molecular Formula | C₁₈H₃₈O₁₀ |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| Storage | 2-8°C |
| IUPAC Name | 2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol |
| InChI | InChI=1S/C18H38O10/c19-1-3-21-5-7-23-9-11-25-13-15-27-17-18-28-16-14-26-12-10-24-8-6-22-4-2-20/h19-20H,1-18H2 |
| InChIKey | YZUUTMGDONTGTN-UHFFFAOYSA-N |
| SMILES | C(COCCOCCOCCOCCOCCOCCOCCOCCO)O |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
